Department of Endocrinology, Trakya University Medical Faculty, Edirne, Turkey.
J Headache Pain. 2011 Jun;12(3):355-60. doi: 10.1007/s10194-011-0306-8. Epub 2011 Feb 18.
The relationship of migraine with cardiovascular diseases has been clarified by many studies, and currently, migraine is suggested to be a systematic vasculopathy. Inflammation, thrombosis and impaired vascular reactivity are the underlying pathophysiological mechanisms of the vasculopathy. In the present study, we aimed to investigate the relationship between prolactin levels and subclinical atherosclerosis risk factors such as soluble CD40 ligand (sCD40L) and high-sensitivity CRP (hsCRP) in migraine patients during interictal period. Fifty female migraine patients and age-matched 25 female control cases were enrolled in the study. Migraine diagnosis was settled according to the ICHD-II diagnostic criteria. A questionnaire was completed about the existence of vascular risk factors. Serum samples were used to measure sCD40L, hsCRP and prolactin levels. No difference was found between the prolactin levels of the migraine patients and the controls. The sCD40L levels were significantly higher in migraine patients (p < 0.001). High-sensitivity CRP levels showed no difference between the groups. There was no correlation between prolactin, sCD40L, and hs-CRP levels in migraine patients. We consider that the migraine patients are prone to subclinical atherosclerosis, but this tendency is independent of prolactin levels.
偏头痛与心血管疾病的关系已被许多研究阐明，目前偏头痛被认为是一种系统性血管病变。炎症、血栓形成和血管反应性受损是血管病变的潜在病理生理机制。在本研究中，我们旨在探讨偏头痛患者在间歇期催乳素水平与可溶性 CD40 配体（sCD40L）和高敏 C 反应蛋白（hsCRP）等亚临床动脉粥样硬化危险因素之间的关系。纳入了 50 名女性偏头痛患者和 25 名年龄匹配的女性对照组。根据 ICHD-II 诊断标准确定偏头痛诊断。完成了关于血管危险因素存在情况的问卷。采集血清样本用于测量 sCD40L、hsCRP 和催乳素水平。偏头痛患者与对照组之间的催乳素水平无差异。偏头痛患者的 sCD40L 水平显著升高（p<0.001）。两组间 hs-CRP 水平无差异。偏头痛患者的催乳素、sCD40L 和 hs-CRP 水平之间无相关性。我们认为偏头痛患者易发生亚临床动脉粥样硬化，但这种趋势与催乳素水平无关。
