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生物信息学工具在病毒表位预测中的应用进展。

Advances of bioinformatics tools applied in virus epitopes prediction.

机构信息

State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, 430071, China.

出版信息

Virol Sin. 2011 Feb;26(1):1-7. doi: 10.1007/s12250-011-3159-4. Epub 2011 Feb 18.

DOI:10.1007/s12250-011-3159-4
PMID:21331885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7090880/
Abstract

In recent years, the in silico epitopes prediction tools have facilitated the progress of vaccines development significantly and many have been applied to predict epitopes in viruses successfully. Herein, a general overview of different tools currently available, including T cell and B cell epitopes prediction tools, is presented. And the principles of different prediction algorithms are reviewed briefly. Finally, several examples are present to illustrate the application of the prediction tools.

摘要

近年来，基于计算的表位预测工具极大地推动了疫苗开发的进展，并且许多工具已经成功地应用于预测病毒中的表位。本文对目前可用的不同工具进行了概述，包括 T 细胞和 B 细胞表位预测工具，并简要回顾了不同预测算法的原理。最后，通过几个示例说明了预测工具的应用。

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本文引用的文献

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Dendritic cell mediated delivery of plasmid DNA encoding LAMP/HIV-1 Gag fusion immunogen enhances T cell epitope responses in HLA DR4 transgenic mice.树突状细胞介导的质粒 DNA 编码 LAMP/HIV-1 Gag 融合免疫原的递呈增强了 HLA-DR4 转基因小鼠中的 T 细胞表位反应。
PLoS One. 2010 Jan 5;5(1):e8574. doi: 10.1371/journal.pone.0008574.
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Identification of a novel conserved HLA-A*0201-restricted epitope from the spike protein of SARS-CoV.从 SARS-CoV 的刺突蛋白中鉴定出一种新型保守的 HLA-A*0201 限制性表位。
BMC Immunol. 2009 Dec 3;10:61. doi: 10.1186/1471-2172-10-61.
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A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults.一项基于新型 HIV 辅助性 T 细胞表位的疫苗在一项针对未感染 HIV 的成年人的 I 期临床试验中引发了细胞因子分泌的 HIV 特异性 CD4+ T 细胞。
Vaccine. 2009 Nov 23;27(50):7080-6. doi: 10.1016/j.vaccine.2009.09.060. Epub 2009 Sep 26.
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Screening and identification of B cell epitopes of structural proteins of foot-and-mouth disease virus serotype Asia1.口蹄疫病毒血清型 Asia1 结构蛋白 B 细胞表位的筛选与鉴定。
Vet Microbiol. 2010 Jan 6;140(1-2):25-33. doi: 10.1016/j.vetmic.2009.07.011. Epub 2009 Jul 10.
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