Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu, Oulu, Finland.
Metab Syndr Relat Disord. 2011 Jun;9(3):203-10. doi: 10.1089/met.2010.0106. Epub 2011 Feb 20.
Resistin is a peptide hormone secreted mainly from human monocytes and macrophages. It has an unclear association with the metabolic syndrome, which is a cluster of cardiovascular risk factors such as glucose intolerance, central obesity, insulin resistance, dyslipidemia, and hypertension. We examined the association of resistin with metabolic syndrome and its components in a population-based cohort.
A subsample of a large Finnish cross-sectional health examination survey (the Health 2000 Survey) was studied. Resistin was measured using an in-house assay based on the DELFIA® technique in 1,508 Finnish men and women aged 45-74 years. Metabolic syndrome was defined according to five different definitions.
Resistin levels were higher in the subjects with metabolic syndrome when compared to the subjects without metabolic syndrome (P < 0.05 for every metabolic syndrome criterion). In logistic regression analysis, a high resistin level was an independent predictor of the prevalence of metabolic syndrome (P < 0.05 for every criterion). Resistin was positively associated with waist circumference, tumor necrosis factor-α, and insulin resistance assessed by the homeostasis model and inversely with total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol after adjusting for age, gender, and body mass index (P < 0.05 for all).
These results clarify the controversial association of resistin in obesity and metabolic syndrome, suggesting that a high resistin level is associated with clustering of metabolic disturbances.
抵抗素是一种主要由人单核细胞和巨噬细胞分泌的肽激素。它与代谢综合征的关系尚不清楚，代谢综合征是一组心血管危险因素的聚集，如葡萄糖耐量受损、中心性肥胖、胰岛素抵抗、血脂异常和高血压。我们在一个基于人群的队列中研究了抵抗素与代谢综合征及其成分的关系。
研究了一项大型芬兰横断面健康检查调查（健康 2000 调查）的子样本。使用基于 DELFIA®技术的内部检测方法在 1508 名年龄在 45-74 岁的芬兰男女中测量抵抗素。根据五种不同的定义来定义代谢综合征。
与无代谢综合征的受试者相比，患有代谢综合征的受试者的抵抗素水平更高（每个代谢综合征标准均 P<0.05）。在逻辑回归分析中，高抵抗素水平是代谢综合征患病率的独立预测因子（每个标准均 P<0.05）。在调整年龄、性别和体重指数后，抵抗素与腰围、肿瘤坏死因子-α和稳态模型评估的胰岛素抵抗呈正相关，与总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇呈负相关（所有 P<0.05）。
这些结果阐明了肥胖和代谢综合征中抵抗素的争议性关联，表明高抵抗素水平与代谢紊乱的聚集有关。
