Reeves Ben M, Kado Joseph, Brook Monica
Fiji School of Medicine, Lautoka Hospital, Fiji Islands.
J Paediatr Child Health. 2011 Jul;47(7):473-8. doi: 10.1111/j.1440-1754.2010.01997.x. Epub 2011 Feb 18.
Rheumatic heart disease poses a huge burden for developing countries, with Pacific Island nations having among the highest prevalence reported in the world. It is recognised that echocardiography is much more sensitive than clinical examination for detection of rheumatic heart disease, but resource and cost limitations are delaying implementation of screening programmes in developing nations. Rapid echocardiography using low-cost portable machines and a non-expert operator may be a useful compromise, allowing widespread screening and control of rheumatic heart disease in developing countries.
In-school echocardiography and clinical examination was carried out on primary school children (aged five to 14) in Lautoka, Fiji. All of the children with abnormal findings were then recalled for complete in-hospital clinical and echocardiographic assessment by a paediatrician with expertise in rheumatic heart disease and echocardiography.
Using screening echocardiography averaging less than 4 min per patient, the prevalence of definite rheumatic heart disease detected by echocardiogram screening was 55.2 per 1000 compared with 11 per 1000 detected by clinical examination (P < 0.001). It was demonstrated that echocardiography is five times more sensitive at detecting rheumatic heart disease compared with clinical examination. A comprehensive screening programme is estimated to cost less than US$40 per patient detected.
This study confirms that Fiji has the highest documented prevalence of rheumatic heart disease in the world. Rapid echocardiography has the potential to screen large numbers of patients by non-specialist operators, which encourages its use in larger scale screening and prevention strategies in developing countries.
风湿性心脏病给发展中国家带来了巨大负担,太平洋岛国的患病率在世界上名列前茅。人们认识到,超声心动图在检测风湿性心脏病方面比临床检查更为敏感,但资源和成本限制阻碍了发展中国家筛查项目的实施。使用低成本便携式机器和非专业操作人员进行快速超声心动图检查可能是一种有效的折衷办法,有助于在发展中国家广泛开展风湿性心脏病的筛查和控制工作。
对斐济劳托卡的小学生(5至14岁)进行校内超声心动图检查和临床检查。然后,所有检查结果异常的儿童被召回,由一位在风湿性心脏病和超声心动图方面有专业知识的儿科医生进行全面的住院临床和超声心动图评估。
使用平均每位患者检查时间不到4分钟的筛查超声心动图,通过超声心动图筛查检测出的确诊风湿性心脏病患病率为每1000人中有55.2例,而通过临床检查检测出的患病率为每1000人中有11例(P<0.001)。结果表明,超声心动图在检测风湿性心脏病方面的敏感性是临床检查的五倍。据估计,一个全面的筛查项目每位被检测患者的成本不到40美元。
本研究证实,斐济是世界上有记录的风湿性心脏病患病率最高的国家。快速超声心动图有潜力由非专业操作人员对大量患者进行筛查,这促使其在发展中国家的大规模筛查和预防策略中得到应用。