Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Department of Paediatric and Adolescent Medicine, Rigshospitalet University Hospital, Copenhagen, Denmark.
Int J Epidemiol. 2022 Oct 13;51(5):1568-1580. doi: 10.1093/ije/dyac024.
The incidences of heart disease (HD) and congenital heart disease (CHD) among Inuit in Greenland (GL) and Denmark (DK) are unknown. This study aims to estimate incidence rates (IRs) of HD and CHD among the young Inuit populations in Greenland and Denmark compared with rates among young non-Inuit populations in the same countries.
A register-based nationwide cohort including all individuals living in Greenland and Denmark from birth to age <40 years through 1989-2014 was formed. Ethnicity was considered Inuit/mixed if at least one parent was registered as being born in Greenland. Information on HD and CHD hospitalization was obtained from national inpatient registers using ICD-8 and ICD-10 codes.
HD IR was lower among individuals living in Greenland compared with those living in Denmark, [73.35GL (95% confidence interval (CI) 68.07 to 79.03)] vs [88.07DK (95% CI 87.38 to 88.76)], whereas CHD IRs were almost similar in the two countries [IR 34.44GL (95% CI 30.89 to 38.40) vs IR 34.67DK (95% CI 34.24 to 35.10)]. Being of Inuit/mixed ethnicity was associated with an increased risk of both HD and CHD compared with non-Inuit in Greenland and Denmark [adjusted hazard ratio HD 2.07GL (95% CI 1.25 to 3.42)] and CHD [2.92GL (95% CI 1.34 to 6.38)].
HD IR was lower in individuals living in Greenland compared with individuals living in Denmark, whereas the CHD IRs were almost the same for both countries. However, the risk of HD including CHD was higher among individuals of Inuit/mixed ethnicity compared with non-Inuit in both countries, suggesting a role of ethnicity among children and younger adults.
格陵兰（GL）和丹麦（DK）因纽特人中心脏病（HD）和先天性心脏病（CHD）的发病率尚不清楚。本研究旨在比较格陵兰和丹麦年轻因纽特人群与同国非因纽特人群的 HD 和 CHD 发病率，以评估发病率（IR）。
本研究构建了一个基于登记的全国性队列，其中包括 1989 年至 2014 年期间在格陵兰和丹麦出生至<40 岁的所有个体。如果至少有一位父母在格陵兰出生，则被视为因纽特/混血。通过使用 ICD-8 和 ICD-10 代码，从国家住院登记处获得 HD 和 CHD 住院信息。
与丹麦相比，生活在格陵兰的个体的 HD 发病率较低[73.35GL（95%置信区间（CI）68.07 至 79.03）]，而两国的 CHD 发病率几乎相似[IR 34.44GL（95%CI 30.89 至 38.40）]。在格陵兰和丹麦，混血儿或因纽特人的种族与 HD 和 CHD 的风险增加相关[调整后的 HR HD 2.07GL（95%CI 1.25 至 3.42）]和 CHD [2.92GL（95%CI 1.34 至 6.38）]。
与丹麦相比，生活在格陵兰的个体的 HD 发病率较低，而两国的 CHD 发病率几乎相同。然而，与非因纽特人相比，混血儿或因纽特人的 HD 包括 CHD 的风险更高，这表明种族在儿童和年轻成年人中发挥了作用。
