Department of Dermatology & STD, VM Medical College & Safdarjang Hospital, New Delhi, India.
J Cosmet Dermatol. 2011 Mar;10(1):51-7. doi: 10.1111/j.1473-2165.2010.00526.x.
Acne scars are difficult to treat. Chemical reconstruction of skin scars (CROSS) is a technique using high strength trichloroacetic acid (TCA) focally on the atrophic acne scars to induce collagenization and cosmetic improvement.
The aim of this study was to evaluate the efficacy and safety of CROSS technique using 100% TCA in ice pick scars in dark skin types IV and V.
Thirty patients with ice pick acne scars were initially primed for 2 weeks before the procedure. The priming agents used were hydroquinone 4% applied in the morning and tretinoin 0.025% in the night. Sunscreens were advised to prevent postinflammatory hyperpigmentation. Subsequently, they underwent focal application of 100% TCA with a wooden toothpick in each individual scar, at 2 weekly intervals, for four sessions. Improvement was assessed by the physician, photographic assessment by an independent investigator, and patient feedback by visual analogue scale after the fourth treatment.
Excellent improvement (more than 70%) was observed in the majority of patients (73.3%), while 20% patients showed good improvement (50-70%) and 6.7% patients had fair results (30-49%) at the end of four sessions. Transient hypopigmentation was observed in one patient and hyperpigmentation in two patients. However, no significant adverse effects such as prolonged pigmentary changes or scarring were noted.
Treatment of ice pick acne scars with the CROSS technique using high strength 100% TCA is a safe, minimally invasive, efficacious, and cost-effective technique in darker skin. Adequate priming and continued use of hydroquinone and tretinoin reduces complications and promotes healing.
痤疮疤痕难以治疗。皮肤疤痕化学重建(CROSS)技术是一种使用高强度三氯乙酸(TCA)聚焦于萎缩性痤疮疤痕以诱导胶原形成和美容改善的技术。
本研究旨在评估 100%TCA 在深色皮肤 IV 型和 V 型冰锥状疤痕中的 CROSS 技术的疗效和安全性。
30 例冰锥状痤疮疤痕患者在治疗前 2 周进行初步治疗。使用的起始剂为 4%氢醌,每日早晨使用,0.025%维甲酸每晚使用。建议使用防晒霜以预防炎症后色素沉着过度。随后,每两周进行一次,共四次,用木制牙签将 100%TCA 局部应用于每个单独的疤痕中。在第四次治疗后,由医生评估改善情况,由独立研究人员进行摄影评估,由患者通过视觉模拟量表进行反馈。
大多数患者(73.3%)观察到显著改善(超过 70%),20%的患者显示良好改善(50-70%),6.7%的患者有中等改善(30-49%)。在一名患者中观察到短暂性色素减退,在两名患者中观察到色素沉着过度。然而,未观察到明显的不良反应,如色素变化或疤痕持续时间延长。
在深色皮肤中,使用高强度 100%TCA 的 CROSS 技术治疗冰锥状痤疮疤痕是一种安全、微创、有效且具有成本效益的技术。适当的起始治疗和持续使用氢醌和维甲酸可减少并发症并促进愈合。