Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.
Chem Biol Drug Des. 2012 Jan;79(1):137-42. doi: 10.1111/j.1747-0285.2011.01105.x. Epub 2011 Nov 4.
The fact that ethosuximide (ETO), phenobarbital (PHO), and barbituric acid (BARB) share structural and pharmacophoric homologies with phenytoin and allantoin, both known to have significant wound-healing properties, prompted us to evaluate them as wound-healing agents. Accordingly, ETO-, PHO-, and BARB-containing ointments were applied onto full-thickness excision and incision wounds created on the dorso-lumbar region of experimental rats. ETO-and PHO-treated incision wounds illustrated significant enhancement in breaking strengths (1380 ± 61 and 1240 ± 42 g, respectively) compared to vehicle controls (1070 ± 18 g) and BARB (1080 ± 45 g). Moreover, biochemical analyses revealed significant increase in hydroxyproline contents in ETO- and PHO-treated wounds compared to vehicle controls. Histological evaluation revealed that both ETO and PHO promoted collagen synthesis and deposition. This is the first time to describe the significant wound-healing merits of ETO and PHO as potential clinical agents for treatment of chronic wounds.
乙琥胺（ETO）、苯巴比妥（PHO）和巴比妥酸（BARB）与均具有显著伤口愈合特性的苯妥英和尿囊素在结构和药效团上具有同源性，这一事实促使我们将它们评估为伤口愈合剂。因此，将含有 ETO、PHO 和 BARB 的软膏应用于实验大鼠背部和腰部的全层切除和切口伤口。与载体对照（1070 ± 18 g）和 BARB（1080 ± 45 g）相比，ETO 和 PHO 处理的切口伤口的断裂强度分别显著增强（分别为 1380 ± 61 和 1240 ± 42 g）。此外，生化分析显示 ETO 和 PHO 处理的伤口羟脯氨酸含量与载体对照相比显著增加。组织学评估显示，ETO 和 PHO 均促进了胶原蛋白的合成和沉积。这是首次描述 ETO 和 PHO 在慢性伤口治疗中的潜在临床用途的显著伤口愈合优点。
