Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756-0001, USA.
Respir Physiol Neurobiol. 2011 Jun 30;177(1):61-5. doi: 10.1016/j.resp.2011.02.006. Epub 2011 Feb 17.
In Wild Type (WT) and serotonin transporter (5HTT) null mice, we studied oxygen consumption, ventilation and heart rate in air and 5% CO(2) at postnatal (P) days P5, P15, and P25 using either a head-out (younger mice) or whole body plethysmograph (older mice). Body weight and temperature did not differ between the groups. Oxygen consumption differed significantly only in females at P15 when it was reduced in 5HTT nulls (P<0.01). Heart rate similarly differed only in female 5HTT nulls at P15 being decreased in both air and CO(2) (P<0.01). Ventilation in air and 5% CO(2) was significant reduced via an effect on tidal volume at P15 (P<0.02) and P25 (P<0.05) but only in males. Ventilation in air and 5% CO(2) was greater in 5HTT null females at P25. We conclude that the gender specific effect (male predominant) on the CO(2) response reported in 5HTT null adult mice (Li and Nattie, 2008, J. Physiol. 586.9, 2321-2329, 2008) appears to have origins in early postnatal life (P15) when ventilation in both air and 5% CO(2) is reduced.
在野生型（WT）和 5-羟色胺转运体（5HTT）缺失小鼠中，我们研究了出生后（P）第 5、15 和 25 天，在空气和 5% CO2 中，使用头部外露（较小的老鼠）或全身 plethysmograph（较大的老鼠）时的耗氧量、通气量和心率。体重和体温在各组之间没有差异。只有在雌性小鼠中，在第 15 天，5HTT 缺失的小鼠耗氧量显著降低（P<0.01）。心率也只有在雌性 5HTT 缺失的小鼠中在第 15 天有显著差异，在空气和 CO2 中都降低（P<0.01）。在第 15 天和第 25 天，通过对潮气量的影响，空气和 5% CO2 中的通气量均显著降低（P<0.02）和（P<0.05），但仅在雄性中。空气和 5% CO2 中的通气量在第 25 天的 5HTT 缺失的雌性小鼠中更大。我们得出结论，在 5HTT 缺失的成年小鼠中报道的 CO2 反应的性别特异性效应（主要是男性）（Li 和 Nattie，2008，J. Physiol. 586.9，2321-2329，2008）似乎起源于出生后早期（第 15 天），此时空气和 5% CO2 中的通气量均降低。
