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比较口服地屈孕酮与孕激素凝胶和微粒化黄体酮用于 1373 例行体外受精妇女的黄体支持：一项随机临床研究。

Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study.

机构信息

School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.

出版信息

Fertil Steril. 2011 May;95(6):1961-5. doi: 10.1016/j.fertnstert.2011.01.148. Epub 2011 Feb 21.

DOI:10.1016/j.fertnstert.2011.01.148
PMID:21333984
Abstract

OBJECTIVE

To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation.

DESIGN

Prospective, randomized clinical study.

SETTING

Institute of Reproductive Medicine, Kolkata, India.

PATIENT(S): A total of 1,373 infertile women undergoing IVF participated.

INTERVENTION(S): Micronized P gel, P capsule, and oral dydrogesterone were administered for luteal support and compared.

MAIN OUTCOME MEASURE(S): Demographic profile and pregnancy and miscarriage rates.

RESULT(S): The overall pregnancy rate and miscarriage rate were comparable among the three groups.

CONCLUSION(S): Oral dydrogesterone seems to be a promising drug for luteal support in woman undergoing IVF.

摘要

目的

比较口服地屈孕酮与微粒化阴道 P 凝胶和微粒化 P 胶囊用于黄体支持的疗效。

设计

前瞻性、随机临床研究。

地点

印度加尔各答生殖医学研究所。

患者

共有 1373 名接受试管婴儿治疗的不孕妇女参与。

干预措施

给予微粒化 P 凝胶、P 胶囊和口服地屈孕酮进行黄体支持，并进行比较。

主要观察指标

人口统计学特征和妊娠及流产率。

结果

三组的总体妊娠率和流产率相似。

结论

口服地屈孕酮似乎是一种有前途的药物，可用于接受试管婴儿治疗的妇女的黄体支持。

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