College of Pharmacy, Zhejiang Chinese Medicine University, Hangzhou 310053, Zhejiang, China.
Neurosci Lett. 2011 Apr 15;493(3):145-8. doi: 10.1016/j.neulet.2011.02.030. Epub 2011 Feb 18.
A rat model of depression has been recently developed using exogenous corticosterone (CORT) administration. This study aimed to examine the antidepressant-like effect and the possible mechanisms of curcumin in a CORT-induced depression model in rats. The results showed that 3-week CORT injections caused depression-like behavior in rats, as indicated by the significant decrease in sucrose consumption and increase in immobility time in the forced swim test. Repeated CORT injections also significantly decreased brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus and frontal cortex of the rats. Treatment of the rats with curcumin significantly suppressed the depression-like behavior and the decrease in brain BDNF levels induced by the repeated CORT injections. The results suggest that curcumin produces an antidepressant-like effect in CORT-treated rats, which is possibly mediated by increasing BDNF expression in the hippocampus and frontal cortex.
最近，通过外源性皮质酮（CORT）给药建立了一种抑郁大鼠模型。本研究旨在探讨姜黄素在 CORT 诱导的抑郁模型大鼠中的抗抑郁样作用及可能机制。结果表明，3 周 CORT 注射可导致大鼠出现抑郁样行为，如在强迫游泳试验中蔗糖消耗显著减少和不动时间增加。重复 CORT 注射还显著降低了大鼠海马和前额皮质中的脑源性神经营养因子（BDNF）蛋白水平。姜黄素处理可显著抑制 CORT 注射引起的抑郁样行为和大脑 BDNF 水平的降低。结果表明，姜黄素在 CORT 处理的大鼠中产生抗抑郁样作用，这可能是通过增加海马和前额皮质中的 BDNF 表达来介导的。
