Department of Epidemiology & Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.
Sci Total Environ. 2011 Apr 15;409(10):1806-10. doi: 10.1016/j.scitotenv.2011.01.045. Epub 2011 Feb 21.
Lead (Pb) levels, delta-aminolevulinic acid dehydratase (ALAD) activities, zinc protoporphyrin (ZPP) levels in blood, and urinary delta-aminolevulinic acid (ALA) and coproporphyrin (CP) concentrations were measured for 318 environmental Pb exposed children recruited from an area of southeast China. The mean of blood lead (PbB) levels was 75.0μg/L among all subjects. Benchmark dose (BMD) method was conducted to present a lower PbB BMD (lower bound of BMD) of 32.4μg/L (22.7) based on ALAD activity than those based on the other three haematological indices, corresponding to a benchmark response of 1%. Childhood intelligence degrees were not associated significantly with ALAD activities or ALA levels. It was concluded that blood ALAD activity is a sensitive indicator of early haematological damage due to low-level Pb exposures for children.
对来自中国东南部某地区的 318 名接触环境铅的儿童进行了血铅 (PbB) 水平、δ-氨基乙酰丙酸脱水酶 (ALAD) 活性、锌原卟啉 (ZPP) 水平以及尿 δ-氨基乙酰丙酸 (ALA) 和粪卟啉 (CP) 浓度的测量。所有受试者的平均血铅 (PbB) 水平为 75.0μg/L。基于 ALAD 活性的基准剂量 (BMD) 方法得出了一个较低的血铅 BMD（BMD 的下限），为 32.4μg/L（22.7），对应的基准反应为 1%。儿童的智力程度与 ALAD 活性或 ALA 水平无显著相关性。因此，血液 ALAD 活性是儿童低水平铅暴露引起早期血液损伤的敏感指标。
