School of Oral and Dental Sciences, University of Bristol, Lower Maudlin Street, Bristol BS1 2LY, UK.
J Dent Res. 2011 Nov;90(11):1271-8. doi: 10.1177/0022034511399096. Epub 2011 Feb 18.
Studies on the adherence properties of oral bacteria have been a major focus in microbiology research for several decades. The ability of bacteria to adhere to the variety of surfaces present in the oral cavity, and to become integrated within the resident microbial communities, confers growth and survival properties. Molecular analyses have revealed several families of Gram-positive bacterial surface proteins, including serine-rich repeat, antigen I/II, and pilus families, that mediate adherence to a variety of salivary and oral bacterial receptors. In Gram-negative bacteria, pili, auto-transporters, and extracellular matrix-binding proteins provide components for host tissue recognition and building of complex microbial communities. Future studies will reveal in greater detail the binding pockets for these adhesin families and their receptors. This information will be crucial for the development of new inhibitors or vaccines that target the functional regions of bacterial proteins that are involved in colonization and pathogenesis.
几十年来，口腔细菌黏附特性的研究一直是微生物学研究的重点。细菌具有黏附口腔内各种表面的能力，并整合到常驻微生物群落中，从而获得生长和存活的特性。分子分析揭示了几种革兰氏阳性菌表面蛋白家族，包括富含丝氨酸的重复序列、抗原 I/II 和菌毛家族，这些家族介导了对各种唾液和口腔细菌受体的黏附。在革兰氏阴性菌中，菌毛、自转运蛋白和细胞外基质结合蛋白为宿主组织识别和复杂微生物群落的构建提供了成分。未来的研究将更详细地揭示这些黏附素家族及其受体的结合口袋。这些信息对于开发针对参与定植和发病机制的细菌蛋白功能区域的新型抑制剂或疫苗至关重要。
