Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, 610041, Chengdu, Sichuan Province, China.
Dig Dis Sci. 2011 Aug;56(8):2227-36. doi: 10.1007/s10620-011-1617-y. Epub 2011 Feb 19.
Studies investigating the associations between tumor necrosis factor-alpha (TNFA) polymorphisms and hepatocellular carcinoma (HCC) risk report conflicting results. We conducted a meta-analysis to assess the association between TNFA gene TNFA-308(G/A), TNFA-238(G/A), TNFA-863(C/A), TNFA-857(C/T), TNFA-1031 (T/C) polymorphisms and HCC susceptibility.
Two investigators independently searched the Medline, Embase, CNKI, and Chinese Biomedicine Database. Summary odds ratios (ORs) and 95% confidence intervals (95% CIs) for TNFA polymorphisms and HCC were calculated in a fixed-effects model (the Mantel-Haenszel method) and a random-effects model (the DerSimonian and Laird method) when appropriate.
This meta-analysis included 17 case-control studies, which included 2,357 HCC cases and 3,161 controls. Overall, the variant genotypes AA/AG of -308G/A were associated with a significantly increased HCC risk, when compared with GG genotype (AA vs. GG, OR=1.97, 95%CI=1.01-3.83; AG vs. GG, OR=1.88, 95%CI=1.23-2.88; AA/AG vs. GG, OR=1.80, 95%CI=1.19-2.72). When stratifying for ethnicity, significantly elevated HCC risk was found among Asians. Moreover, similar results were observed between TNFA-238G/A, TNFA-863C/A polymorphisms and HCC risk among Asians (for -238G/A, AG vs. GG OR=1.63, 95%CI=1.17-2.26, AA/AG vs. GG OR=1.61, 95%CI=1.16-2.24; for -863 C/A, AC vs. CC OR=1.72, 95%CI=1.03-2.88, AA/AC vs. CC OR=1.71, 95%CI=1.02-2.86), while no associations were observed between TNFA-857C/T, TNFA-1031T/C polymorphisms and HCC susceptibility.
This meta-analysis shows that TNFA-308G/A, TNFA-238G/A and TNFA-863C/A polymorphisms may be associated with HCC among Asians. TNFA-857C/T and TNFA-1031T/C polymorphisms were not detected to be related to the risk for HCC.
研究肿瘤坏死因子-α（TNFA）多态性与肝细胞癌（HCC）风险之间的关系的研究报告结果相互矛盾。我们进行了荟萃分析，以评估 TNFA 基因 TNFA-308（G/A）、TNFA-238（G/A）、TNFA-863（C/A）、TNFA-857（C/T）、TNFA-1031（T/C）多态性与 HCC 易感性之间的关联。
两位研究者独立检索了 Medline、Embase、CNKI 和中国生物医学数据库。在适当的情况下，使用固定效应模型（Mantel-Haenszel 方法）和随机效应模型（DerSimonian 和 Laird 方法）计算 TNFA 多态性与 HCC 的汇总比值比（OR）和 95%置信区间（95%CI）。
本荟萃分析包括 17 项病例对照研究，共纳入 2357 例 HCC 病例和 3161 例对照。总体而言，与 GG 基因型相比，-308G/A 的变异基因型 AA/AG 与 HCC 风险显著增加相关（AA 与 GG，OR=1.97，95%CI=1.01-3.83；AG 与 GG，OR=1.88，95%CI=1.23-2.88；AA/AG 与 GG，OR=1.80，95%CI=1.19-2.72）。按种族分层时，在亚洲人群中发现 HCC 风险显著升高。此外，在亚洲人群中，TNFA-238G/A 和 TNFA-863C/A 多态性与 HCC 风险之间也观察到类似的结果（对于-238G/A，AG 与 GG，OR=1.63，95%CI=1.17-2.26，AA/AG 与 GG，OR=1.61，95%CI=1.16-2.24；对于-863 C/A，AC 与 CC，OR=1.72，95%CI=1.03-2.88，AA/AC 与 CC，OR=1.71，95%CI=1.02-2.86），而 TNFA-857C/T 和 TNFA-1031T/C 多态性与 HCC 易感性之间未见关联。
本荟萃分析表明，TNFA-308G/A、TNFA-238G/A 和 TNFA-863C/A 多态性可能与亚洲人群的 HCC 相关。未发现 TNFA-857C/T 和 TNFA-1031T/C 多态性与 HCC 风险相关。
