Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av do Café, s/n, 14040-903, Ribeirão Preto, SP, Brazil.
J Pharm Sci. 2011 Jul;100(7):2849-57. doi: 10.1002/jps.22522. Epub 2011 Feb 18.
The goal of this work was to study the liquid crystalline structure of a nanodispersion delivery system intended to be used in photodynamic therapy after loading with photosensitizers (PSs) and additives such as preservatives and thickening polymers. Polarized light microscopy and light scattering were performed on a standard nanodispersion in order to determine the anisotropy of the liquid crystalline structure and the mean diameter of the nanoparticles, respectively. Small angle X-ray diffraction (SAXRD) was used to verify the influence of drug loading and additives on the liquid crystalline structure of the nanodispersions. The samples, before and after the addition of PSs and additives, were stable over 90 days, as verified by dynamic light scattering. SAXRD revealed that despite the alteration observed in some of the samples analyzed in the presence of photosensitizing drugs and additives, the hexagonal phase still remained in the crystalline phase.
这项工作的目的是研究纳米分散递药系统的液晶结构，该系统旨在负载光敏剂 (PSs) 和添加剂（如防腐剂和增稠聚合物）后用于光动力疗法。通过偏光显微镜和光散射分别对标准纳米分散体进行了研究，以确定液晶结构的各向异性和纳米颗粒的平均直径。小角 X 射线衍射 (SAXRD) 用于验证药物负载和添加剂对纳米分散体液晶结构的影响。通过动态光散射验证，添加 PSs 和添加剂前后的样品在 90 天内稳定。SAXRD 表明，尽管在存在光敏药物和添加剂的一些样品中观察到了一些变化，但在晶相仍保留六方相。
