Fujita M, Kinoshita K, Yawaka Y, Ishimaru M, Oguchi H
Department of Pediatric Dentistry, Hokkaido University, School of Dentistry.
Shoni Shikagaku Zasshi. 1990;28(2):338-45.
This study was conducted to investigate some biochemical characteristics of compound odontoma obtained from three cases, all found in the mandible. The results were compared with data obtained from deciduous teeth (3) and permanent teeth (3). The mole ratios of calcium to inorganic phosphorus (Ca/P) among three groups were deviated between 1.67 and 1.68 in the enamel extracts and between 1.65 and 1.69 in the dentine extracts. No significant differences were found in each case. Amino acid analysis of dentine showed apparent differences among these groups in the degrees of hydroxylation of proline (Hyp/Pro + Hyp) and of lysine (Hyl/Lys + Hyl). Hydroxylation rates of proline were 43.1 +/- 0.98% for the permanent teeth, 44.4 +/- 0.47% for the deciduous teeth and 40.9 +/- 0.44% for the odontoma. Hydroxylation rates of lysine were 32.0 +/- 0.67% for the permanent teeth, 27.3 +/- 0.0% for the deciduous teeth and 26.5 +/- 0.46% for the odontoma. T-test confirmed the significance of the differences between the permanent teeth and odontoma in the case of lysine (p less than 0.5%) and between the deciduous teeth and odontoma in the case of proline (p less than 0.5%). These results suggest the differential organization of dentine matrix between human permanent teeth, deciduous teeth and compound odontoma.
本研究旨在调查从3例下颌骨复合性牙瘤中获取的一些生化特性，并将结果与从乳牙（3颗）和恒牙（3颗）中获得的数据进行比较。三组牙釉质提取物中钙与无机磷的摩尔比（Ca/P）在1.67至1.68之间，牙本质提取物中的该比值在1.65至1.69之间。各病例之间未发现显著差异。牙本质的氨基酸分析显示，这些组在脯氨酸（Hyp/Pro + Hyp）和赖氨酸（Hyl/Lys + Hyl）的羟基化程度上存在明显差异。恒牙的脯氨酸羟基化率为43.1±0.98%，乳牙为44.4±0.47%，牙瘤为40.9±0.44%。赖氨酸的羟基化率在恒牙中为32.0±0.67%，乳牙中为27.3±0.0%，牙瘤中为26.5±0.46%。T检验证实，在赖氨酸方面，恒牙与牙瘤之间存在显著差异（p小于0.5%）；在脯氨酸方面，乳牙与牙瘤之间存在显著差异（p小于0.5%）。这些结果表明，人类恒牙、乳牙和复合性牙瘤之间牙本质基质的组织结构存在差异。
