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[在波哥大两个肾脏单位接受血液透析的慢性肾脏替代治疗患者中的铝含量]

[Aluminium in chronic renal replacement therapy patients undergoing haemodialysis in two renal units in Bogotá].

作者信息

Cárdenas Omayda, Segura Omar, Puentes William, Sanabria Mauricio, Nava Gerardo, Torrenegra Rubén

机构信息

Instituto Nacional de Salud, Bogotá, DC, Colombia.

出版信息

Rev Salud Publica (Bogota). 2010 Aug;12(4):669-81. doi: 10.1590/s0124-00642010000400013.

Abstract

OBJECTIVE

Determining aluminium concentrations in the serum of patients undergoing chronic renal replacement therapy with haemodialysis and concentration in distribution network water and dialysis in two renal units in Bogotá.

MATERIAL AND METHODS

This was a descriptive study of 63 haemodialysed patients and 20 healthy subjects. Aluminium concentration was determined in water and serum using graphite furnace atomic absorption spectrometry with deuterium lamp background corrector.

RESULTS

Average aluminium concentration was 26.5 µg/L in patients (ranging from 11.2 to 49.2 µg/L; 8.03 standard deviation) and 8.05 µg/L in healthy individuals (ranging from undetectable to 17.2 µg/L; 4.31 standard deviation). Aluminium concentration in dialysis water and distribution network water was below 2 µg/L and 200 µg/L, respectively.

CONCLUSIONS

Aluminium concentration in water and serum in this study was below international standard values, thereby indicating appropriate treatment. Additionally, aluminium concentration in pre-HD and post-HD sera was below that reported previously. Aluminium hydroxide uptake increases aluminium concentration in serum. Personal situation regarding age, gender, civil and work status were not risk factors determining aluminium concentrations in serum.

摘要

目的

测定在波哥大两个肾脏单位接受慢性血液透析肾替代治疗患者的血清铝浓度以及配水网络水和透析液中的铝浓度。

材料与方法

这是一项对63例血液透析患者和20名健康受试者的描述性研究。使用带氘灯背景校正器的石墨炉原子吸收光谱法测定水和血清中的铝浓度。

结果

患者的平均铝浓度为26.5μg/L(范围为11.2至49.2μg/L;标准差为8.03),健康个体的平均铝浓度为8.05μg/L(范围为未检测到至17.2μg/L;标准差为4.31)。透析用水和配水网络水中的铝浓度分别低于2μg/L和200μg/L。

结论

本研究中水和血清中的铝浓度低于国际标准值,从而表明治疗得当。此外,血液透析前和血液透析后血清中的铝浓度低于先前报道的值。服用氢氧化铝会增加血清中的铝浓度。年龄、性别、公民身份和工作状态等个人情况不是决定血清铝浓度的风险因素。

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