Milich D R
Department of Molecular Biology, Research Institute of Scripps Clinic, La Jolla, CA 92037.
Semin Immunol. 1990 Sep;2(5):307-15.
There is great interest in the use of synthetic peptides for vaccine purposes. Chemical synthesis guarantees an unlimited source of chemically stable protein at relatively low cost. Additionally, synthetic peptide antigens have been demonstrated to immunize T helper cells, cytotoxic T cells, and B cells which are reactive with representative native protein antigens. However, a number of obstacles to the use of peptide antigens have also been elucidated. The purpose of this review is to examine our current understanding of peptide antigens as immunogens, and the advantages and disadvantages of their use in vaccine design.
人们对将合成肽用于疫苗目的有着浓厚的兴趣。化学合成以相对较低的成本保证了化学稳定蛋白质的无限来源。此外，合成肽抗原已被证明可免疫与代表性天然蛋白质抗原发生反应的辅助性T细胞、细胞毒性T细胞和B细胞。然而，使用肽抗原的一些障碍也已被阐明。本综述的目的是审视我们目前对作为免疫原的肽抗原的理解，以及它们在疫苗设计中使用的优缺点。
