Sood A, Venugopalan P, Mysore N, Vyas S P
Department of Pharmaceutical Sciences, Dr H.S. Gour Vishwavidyalaya, India.
Indian J Exp Biol. 1998 Sep;36(9):849-61.
For induction of humoral or cell-mediated immunity, development of synthetic peptide vaccines present a novel approach and a better alternative to conventional vaccines. Construction of synthetic peptides that mimic antigenic sites is the basis of this approach. In this article various methodologies involved in the peptide synthesis are discussed. This is followed by a discussion on the strategies involved in rendering poor or non-immunogenic peptides immunogenic. These include coupling to large carrier proteins, polymeric presentation and incorporation of an identified Th cell epitope into the peptide.
为诱导体液免疫或细胞介导的免疫，合成肽疫苗的研发提供了一种新方法，是传统疫苗的更好替代方案。构建模拟抗原位点的合成肽是该方法的基础。本文讨论了肽合成中涉及的各种方法。随后讨论了使弱免疫原性或无免疫原性的肽具有免疫原性的策略。这些策略包括与大载体蛋白偶联、聚合物呈递以及将已鉴定的Th细胞表位掺入肽中。
