Mayer Débora Lopes Bunzen, Araújo Juliana Gusmão de, Leal Mariana de Carvalho, Caldas Neto Silvio da Silva, Ataíde Rafael Figueiredo, Mello Roberto José Vieria de
Substtuta da Disciplina de ORL da Universidade Federal de Pernambuco--UFPE.
Braz J Otorhinolaryngol. 2011 Jan-Feb;77(1):44-50. doi: 10.1590/S1808-86942011000100008.
New developments on biomaterials are important in surgery. The behavior of a new membrane produced from sugarcane will be evaluated in the middle ear of rats. This study analyzed the results from the interaction of the sugarcane-base biopolymer membrane in the middle ear of a rat. We ran an experimental, prospective, paired study with 24 Wistar rats. The sugarcane-base polymer membrane was inoculated in the right ear; and an autologous fascia in the left ear. The rats were divided in 3 groups of 8, and slaughtered at 4, 8 and 12 weeks after surgery. Histological analyses were performed on the rats' middle ear mucosa and their tympanic membranes. There was an inflammatory reaction on the experimental group and middle ear subacute exudate in 50%of the cases; 30% chronic exudate; and 20% was normal. In the control group there was only one case of exudate. The inflammation was initially described as intense, but it decreased over time. Myringosclerosis was observed in both groups. The sugarcane biopolymer membrane was absorbed later when compared with fascia. The sugarcane biopolymer membrane induced an inflammatory reaction in the middle ear which decreased over time, and mild fibrosis. Future studies can indicate its use in otolaryngology.
生物材料的新进展在外科手术中具有重要意义。一种由甘蔗制成的新型膜的性能将在大鼠中耳进行评估。本研究分析了甘蔗基生物聚合物膜在大鼠中耳相互作用的结果。我们对24只Wistar大鼠进行了一项实验性、前瞻性、配对研究。将甘蔗基聚合物膜植入右耳；左耳植入自体筋膜。将大鼠分为3组，每组8只，并在手术后4周、8周和12周进行宰杀。对大鼠中耳黏膜及其鼓膜进行组织学分析。实验组出现炎症反应，50%的病例中耳有亚急性渗出物；30%为慢性渗出物；20%正常。对照组仅有1例渗出物。炎症最初被描述为强烈，但随时间推移而减轻。两组均观察到鼓膜硬化。与筋膜相比，甘蔗生物聚合物膜后期被吸收。甘蔗生物聚合物膜在中耳引发炎症反应，该反应随时间减轻，并伴有轻度纤维化。未来的研究可以表明其在耳鼻喉科的应用。
