Molina Fernando Drimel, Suman Marcela, Carvalho Thiago Bittencourt Ottoni de, Piatto Vânia Belintani, Taboga Sebastião Roberto, Maniglia José Victor, Tognola Waldir Antônio
Ambulatório de ORL e CCP, FAMERP, FUNFARME, SP.
Braz J Otorhinolaryngol. 2011 Jan-Feb;77(1):88-95. doi: 10.1590/s1808-86942011000100015.
Males with obstructive sleep apnea syndrome (OSAS) may present decreased testosterone serum levels because of hypoxemia. To correlate testosterone levels in OSAS patients with laboratory parameters. 103 registries of OSAS patients were reviewed from 2002 to 2009. The following data collected: age when polysomnography was done, hematocrit and hemoglobin levels, total testosterone serum levels, BMI, apnea/hypopnea index (AHI), and O2 saturation. A cross-sectional retrospective case study. 79 patients (77%) had no hormonal changes, and 24 patients (23%) had decreased serum levels. In patients with normal testosterone levels, 70% were overweight; 63% with altered testosterone levels had obesity grade I (<0.05). Patients with altered testosterone levels had significantly lower average doses of Ht, Hb and androgen compared to patients without altered androgen levels. The average BMI of patients with altered hormone levels was significantly higher compared to patients with normal hormone levels. The relationship between morning testosterone levels and obesity, and to a lesser degree age, AHI and hypoxemia may be the cause of central suppression of testosterone in these patients. Decreased blood HT and HB levels may be related to lower levels of circulating testosterone.
患有阻塞性睡眠呼吸暂停综合征（OSAS）的男性可能由于低氧血症而出现血清睾酮水平下降。为了将OSAS患者的睾酮水平与实验室参数相关联。回顾了2002年至2009年期间103例OSAS患者的记录。收集了以下数据：进行多导睡眠图检查时的年龄、血细胞比容和血红蛋白水平、血清总睾酮水平、体重指数（BMI）、呼吸暂停/低通气指数（AHI）和血氧饱和度。一项横断面回顾性病例研究。79例患者（77%）无激素变化，24例患者（23%）血清水平下降。在睾酮水平正常的患者中，70%超重；睾酮水平改变的患者中有63%为I级肥胖（<0.05）。与雄激素水平未改变的患者相比，雄激素水平改变的患者的平均血细胞比容、血红蛋白和雄激素剂量显著更低。激素水平改变的患者的平均BMI显著高于激素水平正常的患者。早晨睾酮水平与肥胖之间的关系，以及在较小程度上与年龄、AHI和低氧血症之间的关系，可能是这些患者睾酮中枢抑制的原因。血液中血细胞比容和血红蛋白水平降低可能与循环睾酮水平较低有关。
