Fronza Andressa Boer, Barreto Daniele Coronel Menna, Tochetto Tânia Maria, Cruz Ivana Batrice Mânica da, Silveira Aron Ferreira da
Universidade Federal de Santa Maria, São Paulo.
Braz J Otorhinolaryngol. 2011 Jan-Feb;77(1):107-14. doi: 10.1590/s1808-86942011000100018.
Efferent auditory pathways modulate outer hair cells of the cochlea, protect against noise, and improve the detection of sound sources in noisy environments. Genotoxicity is DNA damage. To study the association between auditory pathway efferent functions with genotoxic markers. The study also considered smoking and gender as two main variables. A prospective-clinical, quantitative, cross-sectional, contemporary study. The function of efferent auditory pathways and genotoxicity tests in 60 healthy young subjects were assessed. The mean age of subjects was 24.86 years +/- 3.68 years; there were 30 males and 30 females, 15 of each gender smokers and 15 non-smokers. Male smokers had a higher incidence of DPOEA suppression effect at 2000 and 6000 Hz in the left ear; female smokers had a higher prevalence of complaints of difficulty to hear in noisy environments; smokers and women had a higher mean DNA damage; subjects with complaints of hearing loss and tinnitus had higher genotoxicity. In young normal-hearing adults that complain about efferent auditory pathways functions, such as tinnitus and hearing impairment, there are possible associations with genotoxicity; interactions between gender and smoking are considered.
传出性听觉通路调节耳蜗的外毛细胞，抵御噪音，并改善在嘈杂环境中对声源的检测。基因毒性是指DNA损伤。为研究听觉通路传出功能与基因毒性标志物之间的关联。该研究还将吸烟和性别视为两个主要变量。这是一项前瞻性临床、定量、横断面、当代研究。评估了60名健康年轻受试者的传出性听觉通路功能和基因毒性测试。受试者的平均年龄为24.86岁±3.68岁；有30名男性和30名女性，每种性别中有15名吸烟者和15名非吸烟者。男性吸烟者左耳在2000Hz和6000Hz时DPOAE抑制效应的发生率更高；女性吸烟者在嘈杂环境中听力困难的主诉患病率更高；吸烟者和女性的平均DNA损伤更高；有听力损失和耳鸣主诉的受试者基因毒性更高。在抱怨传出性听觉通路功能（如耳鸣和听力障碍）的年轻听力正常成年人中，可能与基因毒性存在关联；考虑了性别与吸烟之间的相互作用。
