Montreal Heart Institute, 5000 Bélanger Street, Montreal, QC, Canada.
Hum Genet. 2011 May;129(5):465-72. doi: 10.1007/s00439-011-0969-x. Epub 2011 Feb 22.
Adult height is a classic polygenic trait of high narrow-sense heritability (h (2) = 0.8). In the late nineteenth to early twentieth century, variation in adult height was used as a model to set the foundation of the fields of statistics and quantitative genetics. More recently, with our increasing knowledge concerning the extent of genetic variation in the human genome, human geneticists have used genome-wide association studies to identify hundreds of loci robustly associated with adult height, providing new insights into human growth and development, and into the architecture of complex human traits. In this review, I highlight the progress made in the last 2 years in understanding how genetic variation controls height variation in humans, including non-Caucasian populations and children.
成人身高是一种具有高度狭义遗传力（h (2) = 0.8）的经典多基因特征。在 19 世纪末到 20 世纪初，成人身高的变化被用作统计学和数量遗传学领域的基础模型。最近，随着我们对人类基因组中遗传变异程度的认识不断增加，人类遗传学家利用全基因组关联研究鉴定了数百个与成人身高显著相关的基因座，为人类生长发育以及复杂人类特征的结构提供了新的见解。在这篇综述中，我重点介绍了过去 2 年中在理解遗传变异如何控制人类身高变异方面所取得的进展，包括非白种人群和儿童。
