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通过制备性超速离心从血清中分离和分析脂蛋白。

Lipoprotein isolation and analysis from serum by preparative ultracentrifugation.

作者信息

Wasan K M, Cassidy S M, Kennedy A L, Peteherych K D

机构信息

Division of Pharmaceutics and Biopharmaceutics, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada.

出版信息

Methods Mol Med. 2001;52:27-35. doi: 10.1385/1-59259-073-X:27.

DOI:10.1385/1-59259-073-X:27
PMID:21340929
Abstract

Plasma lipoproteins are a heterogeneous population of soluble, macromolecular aggregates of lipids and proteins. They are responsible for the transport of waterinsoluble nutrients through the vascular and extravascular fluids from their site of synthesis or absorption to peripheral tissues (1,2). These hydrophobic nutrients (triacylglycerols [TGs] and cholesteryl esters [CEs]) are delivered from the liver and intestine to other tissues in the body for storage or catabolism in the production of energy. Lipoproteins are also known to be involved in other biological processes, including coagulation and tissue repair as well as immune reactions (3,4).

摘要

血浆脂蛋白是脂质和蛋白质的可溶性大分子聚集体的异质群体。它们负责将水不溶性营养物质通过血管和血管外液从其合成或吸收部位运输到外周组织(1,2)。这些疏水性营养物质(三酰甘油[TGs]和胆固醇酯[CEs])从肝脏和肠道输送到身体其他组织,用于储存或在能量产生过程中进行分解代谢。脂蛋白还参与其他生物学过程,包括凝血、组织修复以及免疫反应(3,4)。

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1
Lipoprotein isolation and analysis from serum by preparative ultracentrifugation.通过制备性超速离心从血清中分离和分析脂蛋白。
Methods Mol Med. 2001;52:27-35. doi: 10.1385/1-59259-073-X:27.
2
Role of plasma lipoproteins in modifying the toxic effects of water-insoluble drugs: studies with cyclosporine A.血浆脂蛋白在改变水不溶性药物毒性作用中的作用:环孢素A的研究
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Lipoprotein physiology and its relationship to atherogenesis.脂蛋白生理学及其与动脉粥样硬化形成的关系。
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Plasma lipid transport.血浆脂质转运
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[Lipoprotein metabolism].[脂蛋白代谢]
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S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease.血清高密度脂蛋白部分中 S1P、二氢-S1P 和 C24:1-神经酰胺的水平与缺血性心脏病的发生呈负相关。
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