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以rpsL作为显性负选择标记在结核分枝杆菌和卡介苗中的基因替换

Gene Replacement in Mycobacterium tuberculosis and Mycobacterium bovis BCG Using rpsL as a Dominant Negative Selectable Marker.

作者信息

Sander P, Springer B, Böttger E C

出版信息

Methods Mol Med. 2001;54:93-104. doi: 10.1385/1-59259-147-7:093.

DOI:10.1385/1-59259-147-7:093
PMID:21341071
Abstract

Much progress has been made in mycobacterial research in general and in mycobacterial genetics in particular during the past 10 yr. The complete genome sequences of two isolates of Mycobacterium tuberculosis, the widely distributed laboratory strain M. tuberculosis H37Rv (1) and a clinical isolate CDC 1551 ( http://www.tigr.org ), have recently been determined, thus providing a complete blueprint of the genetic make-up of this pathogen.

摘要

在过去10年里，分枝杆菌研究总体上取得了很大进展，尤其是分枝杆菌遗传学方面。结核分枝杆菌的两个菌株，即广泛分布的实验室菌株结核分枝杆菌H37Rv(1)和临床分离株CDC 1551( http://www.tigr.org )的完整基因组序列最近已被确定，从而为这种病原体的基因组成提供了完整的蓝图。

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Methods Mol Med. 2001;54:93-104. doi: 10.1385/1-59259-147-7:093.
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