Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, Brazil; Programa de Pós-Graduação em Bioquímica Toxicológica, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Brazil.
Phytother Res. 2011 Sep;25(9):1367-74. doi: 10.1002/ptr.3437. Epub 2011 Feb 22.
The aim of the present study was to evaluate the associations of metabolic disorders and anthropometric and biochemical biomarkers of lipid, glucose and oxidative metabolism and the habitual ingestion of guaraná (Paullinia cupana, Mart. Var. sorbilis) by an elderly population residing in the Amazon Riverine region of the Maués municipality (Brazil). A case-controlled study was performed that included 637 elderly (≥60 years of age) patients classified as either those who habitually drank guaraná (GI, n = 421) or those who never drank guaraná (NG, n = 239) based upon their self-reported intake of guaraná. Indeed, the prevalence of various metabolic disorders was associated with guaraná ingestion. The prevalence of hypertension, obesity and metabolic syndrome in the GI group was lower than the prevalence found in the NG group. The NG group exhibited lower systolic and diastolic blood pressure values. The males in the GI group exhibited a lower waist circumference, on average, than the circumference found in the NG group, whereas the females in the GI group had lower cholesterol (total and LDL-c) levels than the control cohort. Additionally, a significant association was found between lower levels of advanced oxidative protein product (AOPP) and habitual guaraná consumption. The results constitute the first epidemiological study to suggest a potentially protective effect of habitual guaraná ingestion against metabolic disorders in elderly subjects.
本研究旨在评估代谢紊乱以及脂质、葡萄糖和氧化代谢的人体测量学和生化生物标志物与瓜拉那（Paullinia cupana，Mart. Var. sorbilis）习惯性摄入之间的关联，该研究对象为居住在巴西 Maués 市亚马逊河地区的老年人群。本研究开展了一项病例对照研究，共纳入 637 名老年人（≥60 岁），根据其对瓜拉那的自我报告摄入量将其分为习惯性饮用瓜拉那组（GI，n=421）和从不饮用瓜拉那组（NG，n=239）。实际上，各种代谢紊乱的患病率与瓜拉那的摄入有关。在 GI 组中，高血压、肥胖和代谢综合征的患病率低于 NG 组。GI 组的收缩压和舒张压值较低。GI 组的男性平均腰围小于 NG 组，而 GI 组的女性总胆固醇（TC 和 LDL-c）水平低于对照组。此外，还发现高水平的晚期氧化蛋白产物（AOPP）与习惯性瓜拉那摄入之间存在显著关联。研究结果首次表明，习惯性瓜拉那摄入可能对老年人群的代谢紊乱具有保护作用。
