聚（二醇-共-柠檬酸酯）作为新型的弹性周细胞包裹物，可减少内膜增生。
Poly(diol-co-citrate)s as novel elastomeric perivascular wraps for the reduction of neointimal hyperplasia.
机构信息
Biomedical Engineering Department, Northwestern University, Evanston, IL 60208, USA.
出版信息
Macromol Biosci. 2011 May 12;11(5):700-9. doi: 10.1002/mabi.201000509. Epub 2011 Feb 21.
Abstract
The synthesis of poly(diol-co-citrate) elastomers that are biocompatible with vascular cells and can modulate the kinetics of the NO release based on the diol of selection is reported. NO-mediated cytostatic or cytotoxic effects can be controlled depending on the NO dose and the exposure time. When implanted in vivo in a rat carotid artery injury model, these materials demonstrate a significant reduction of neointimal hyperplasia. This is the first report of a NO-releasing polymer fabricated in the form of an elastomeric perivascular wrap for the treatment of neointimal hyperplasia. These elastomers also show promise for other cardiovascular pathologies where NO-based therapies could be beneficial.
摘要
报道了一种聚（二醇-共-柠檬酸酯）弹性体的合成方法，该弹性体与血管细胞具有生物相容性，并可以根据所选二醇来调节 NO 释放的动力学。NO 介导的细胞抑制或细胞毒性作用可以根据 NO 剂量和暴露时间来控制。当将这些材料植入大鼠颈动脉损伤模型的体内时，它们表现出对新生内膜增生的显著抑制。这是首次报道以弹性血管周围包裹物的形式制备用于治疗新生内膜增生的 NO 释放聚合物。这些弹性体在其他可能受益于基于 NO 的治疗方法的心血管疾病中也具有应用前景。
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