Wang Min, Xu Peng, Lei Bo
Honghui Hospital, Xi'an Jiaotong University, Xi'an, 710000, China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710000, China.
Bioact Mater. 2022 May 7;19:511-537. doi: 10.1016/j.bioactmat.2022.04.027. eCollection 2023 Jan.
Developing bioactive biomaterials with highly controlled functions is crucial to enhancing their applications in regenerative medicine. Citrate-based polymers are the few bioactive polymer biomaterials used in biomedicine because of their facile synthesis, controllable structure, biocompatibility, biomimetic viscoelastic mechanical behavior, and functional groups available for modification. In recent years, various multifunctional designs and biomedical applications, including cardiovascular, orthopedic, muscle tissue, skin tissue, nerve and spinal cord, bioimaging, and drug or gene delivery based on citrate-based polymers, have been extensively studied, and many of them have good clinical application potential. In this review, we summarize recent progress in the multifunctional design and biomedical applications of citrate-based polymers. We also discuss the further development of multifunctional citrate-based polymers with tailored properties to meet the requirements of various biomedical applications.
开发具有高度可控功能的生物活性生物材料对于增强其在再生医学中的应用至关重要。基于柠檬酸盐的聚合物是少数用于生物医学的生物活性聚合物生物材料，因为它们易于合成、结构可控、具有生物相容性、具有仿生粘弹性力学行为以及有可供修饰的官能团。近年来，基于柠檬酸盐的聚合物的各种多功能设计和生物医学应用，包括心血管、骨科、肌肉组织、皮肤组织、神经和脊髓、生物成像以及药物或基因递送等，都得到了广泛研究，其中许多具有良好的临床应用潜力。在本综述中，我们总结了基于柠檬酸盐的聚合物在多功能设计和生物医学应用方面的最新进展。我们还讨论了具有定制特性的多功能柠檬酸盐基聚合物的进一步发展，以满足各种生物医学应用的需求。
