Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.
Department of Histology and Embryology, School of Basic Medical Sciences, Department of Orthopedic Surgery, The Third Affiliated Hospital of Southern Medical University, Southern Medical University, Guangzhou, 510515, P. R. China.
Adv Mater. 2024 Aug;36(32):e2402871. doi: 10.1002/adma.202402871. Epub 2024 Jun 11.
Citrate-based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these polymers exhibit a wide range of material and bioactive properties, enabling them to regulate cell metabolism and stem cell differentiation through energy metabolism, metabonegenesis, angiogenesis, and immunomodulation. Moreover, the recent US Food and Drug Administration (FDA) clearance of the biodegradable poly(octamethylene citrate) (POC)/hydroxyapatite-based orthopedic fixation devices represents a translational research milestone for biomaterial science. POC joins a short list of biodegradable synthetic polymers that have ever been authorized by the FDA for use in humans. The clinical success of POC has sparked enthusiasm and accelerated the development of next-generation citrate-based biomaterials. This review presents a comprehensive, forward-thinking discussion on the pivotal role of citrate chemistry and metabolism in various tissue regeneration and on the development of functional citrate-based metabotissugenic biomaterials for regenerative engineering applications.
基于柠檬酸盐的可生物降解聚合物已成为一种独特的生物材料平台，具有广泛的医疗应用潜力。通过利用其多样的化学性质，这些聚合物表现出广泛的材料和生物活性特性，使它们能够通过能量代谢、代谢骨生成、血管生成和免疫调节来调节细胞代谢和干细胞分化。此外，最近美国食品和药物管理局 (FDA) 批准了可生物降解的聚（辛烷撑柠檬酸）（POC）/羟基磷灰石骨科固定装置，这是生物材料科学转化研究的一个里程碑。POC 加入了由 FDA 批准用于人体的少数几种可生物降解合成聚合物之列。POC 的临床成功激发了热情并加速了下一代基于柠檬酸盐的生物材料的开发。本综述全面、前瞻性地讨论了柠檬酸盐化学和代谢在各种组织再生中的关键作用，以及用于再生工程应用的功能性基于柠檬酸盐的代谢生材料的开发。
