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[关于树鼩作为潜在丙型肝炎动物模型的丙型肝炎病毒受体的研究进展]

[Progress in studies on HCV receptor of Tupaia as a potential hepatitis C animal model].

作者信息

Li Yao, Dai Jie-Jie, Sun Xiao-Mei, Xia Xue-Shan

机构信息

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming Yunnan 650224, China.

出版信息

Dongwuxue Yanjiu. 2011 Feb;32(1):97-103. doi: 10.3724/SP.J.1141.2011.01097.

Abstract

Hepatitis C virus is a prevalent and globally distributed human pathogen that seriously harmful to public health. However, the development of therapy and vaccine was impeded by the lack of suit small animal models. Herein, we introduce the characters of HCV replication. Taken the HCV cellular receptors as the viewpoint, the potentiality of tupaia as hepatitis C animal model is discussed at the molecular level by comparing of present animal model.

摘要

丙型肝炎病毒是一种广泛流行且分布于全球的人类病原体,对公众健康危害严重。然而,由于缺乏合适的小动物模型,治疗方法和疫苗的研发受到了阻碍。在此,我们介绍丙型肝炎病毒复制的特点。从丙型肝炎病毒细胞受体的角度出发,通过与现有动物模型进行比较,在分子水平上探讨了树鼩作为丙型肝炎动物模型的潜力。

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