Pivovarov Iu P, Sheina N I, Ivanov N G, Korolik V V, Skriabina E G
Gig Sanit. 2010 Sep-Oct(5):9-12.
The state-of-the-art of hygienic standardization of biotechnological strains of microorganisms is considered. The last century's investigations accumulated abundant experimental data on the estimation of the adverse effect of the strains, formulated main guidelines for evaluating the negative activity of producing strains, and proposed a schematic diagram for toxicological and hygienic investigations of new biotechnological strains. Further studies made it possible to elaborate their human hazard classification, to improve study programs, to substantiate a priority list, and to develop approaches to assessing the occupational microbiological risk.
本文探讨了生物技术微生物菌株卫生标准化的最新进展。上个世纪的研究积累了大量关于菌株不良影响评估的实验数据，制定了评估生产菌株负面活性的主要指导方针，并提出了新生物技术菌株毒理学和卫生学研究的示意图。进一步的研究使得详细阐述其对人类的危害分类、改进研究方案、确定优先事项清单以及制定评估职业微生物风险的方法成为可能。
