Sheina N I, Zholdakova Z I, Ivanov N G
Gig Sanit. 2010 Sep-Oct(5):39-42.
The pattern of the negative effect of biotechnological strains belonging to different taxons was experimentally studied. The effect of the strains manifested as imbalance of immunocompetent cells, development of immediate and delayed hypersensitivity, and altered qualitative and quantitative characteristics of the autochtonic microflora of the intestine. The minimum acting (10(5) cells/l) and non-acting (10(4) cells/l) enteral exposure levels were determined for the bulk of the test strains. Analysis of the authors' findings and the data available in the literature made it possible to propose a study program on the hygienic regulation and standardization of industrial microorganisms and their based microbiological products in the reservoir water.
对属于不同分类群的生物技术菌株的负面影响模式进行了实验研究。这些菌株的影响表现为免疫活性细胞失衡、速发型和迟发型超敏反应的发展以及肠道固有微生物群的定性和定量特征改变。确定了大部分测试菌株的最小作用（10⁵ 个细胞/升）和无作用（10⁴ 个细胞/升）肠内暴露水平。对作者的研究结果和文献中的现有数据进行分析，使得有可能提出一项关于水库水中工业微生物及其基础微生物产品的卫生监管和标准化的研究计划。
