[Problem in the hygienic regulation and standardization of biotechnological strains in reservoir water].

The pattern of the negative effect of biotechnological strains belonging to different taxons was experimentally studied. The effect of the strains manifested as imbalance of immunocompetent cells, development of immediate and delayed hypersensitivity, and altered qualitative and quantitative characteristics of the autochtonic microflora of the intestine. The minimum acting (10(5) cells/l) and non-acting (10(4) cells/l) enteral exposure levels were determined for the bulk of the test strains. Analysis of the authors' findings and the data available in the literature made it possible to propose a study program on the hygienic regulation and standardization of industrial microorganisms and their based microbiological products in the reservoir water.