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Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk.

作者信息

Padler-Karavani Vered, Varki Ajit

机构信息

Glycobiology Research and Training Center, Department of Medicine, University of California at San Diego, La Jolla, CA, USA.

出版信息

Xenotransplantation. 2011 Jan-Feb;18(1):1-5. doi: 10.1111/j.1399-3089.2011.00622.x.

DOI:10.1111/j.1399-3089.2011.00622.x
PMID:21342282
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3098739/
Abstract
摘要

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2
Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies.异种细胞中 N-羟乙酰神经氨酸和 Galα1-3Galβ1-4GlcNAc 表位的缺乏可减弱人源天然抗体的细胞毒性。
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本文引用的文献

1
Deficiency of N-glycolylneuraminic acid and Galα1-3Galβ1-4GlcNAc epitopes in xenogeneic cells attenuates cytotoxicity of human natural antibodies.异种细胞中 N-羟乙酰神经氨酸和 Galα1-3Galβ1-4GlcNAc 表位的缺乏可减弱人源天然抗体的细胞毒性。
Xenotransplantation. 2010 Nov-Dec;17(6):440-8. doi: 10.1111/j.1399-3089.2010.00610.x.
2
Reduction of N-glycolylneuraminic acid in human induced pluripotent stem cells generated or cultured under feeder- and serum-free defined conditions.无血清无饲养层条件下诱导多能干细胞生成或培养过程中 N-羟乙酰神经氨酸的减少。
PLoS One. 2010 Nov 23;5(11):e14099. doi: 10.1371/journal.pone.0014099.
3
The sialome--far more than the sum of its parts.唾液组学——远不止其各部分之和。
OMICS. 2010 Aug;14(4):455-64. doi: 10.1089/omi.2009.0148.
4
Implications of the presence of N-glycolylneuraminic acid in recombinant therapeutic glycoproteins.N-羟乙酰神经氨酸存在于重组治疗性糖蛋白中的意义。
Nat Biotechnol. 2010 Aug;28(8):863-7. doi: 10.1038/nbt.1651. Epub 2010 Jul 25.
5
Investigation of potential carbohydrate antigen targets for human and baboon antibodies.人源和狒狒抗体潜在碳水化合物抗原靶标的研究。
Xenotransplantation. 2010 May-Jun;17(3):197-206. doi: 10.1111/j.1399-3089.2010.00579.x.
6
Colloquium paper: uniquely human evolution of sialic acid genetics and biology.学术研讨会论文：唾液酸遗传学和生物学的独特人类进化。
Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2(Suppl 2):8939-46. doi: 10.1073/pnas.0914634107. Epub 2010 May 5.
7
Immunological property of antibodies against N-glycolylneuraminic acid epitopes in cytidine monophospho-N-acetylneuraminic acid hydroxylase-deficient mice.抗 N-羟乙酰神经氨酸表位抗体的免疫特性在胞苷单磷酸 N-乙酰神经氨酸羟化酶缺陷型小鼠中。
J Immunol. 2010 Mar 15;184(6):3269-75. doi: 10.4049/jimmunol.0902857. Epub 2010 Feb 19.
8
Structural characterization of alpha1,3-galactosyltransferase knockout pig heart and kidney glycolipids and their reactivity with human and baboon antibodies.α1,3-半乳糖基转移酶敲除猪心、肾糖脂的结构特征及其与人及狒狒抗体的反应性。
Xenotransplantation. 2010 Jan-Feb;17(1):48-60. doi: 10.1111/j.1399-3089.2009.00564.x.
9
Human CMP-N-acetylneuraminic acid hydroxylase is a novel stem cell marker linked to stem cell-specific mechanisms.人 CMP-N-乙酰神经氨酸羟化酶是一种新型的干细胞标志物，与干细胞特异性机制相关。
Stem Cells. 2010 Feb;28(2):258-67. doi: 10.1002/stem.250.
10
Reduction of N-glycolylneuraminic acid xenoantigen on human adipose tissue-derived stromal cells/mesenchymal stem cells leads to safer and more useful cell sources for various stem cell therapies.降低人脂肪组织来源的基质细胞/间充质干细胞上的 N-羟乙酰神经氨酸异种抗原，可使各种干细胞治疗的细胞来源更安全、更有用。
Tissue Eng Part A. 2010 Apr;16(4):1143-55. doi: 10.1089/ten.TEA.2009.0386.