Department of Dermatology, Graduate School of Medicine, Dongguk University, Seoul, Gyeonggi-do, South Korea.
Dermatol Surg. 2011 Mar;37(3):336-41. doi: 10.1111/j.1524-4725.2011.01882.x. Epub 2011 Feb 22.
Intense pulsed light (IPL) and the microneedle therapy system (MTS) are currently available for the treatment of scars. Greater collagen deposition has been proposed as a mechanism for the treatment of scars.
To compare the effects of IPL and MTS on collagen deposition.
Fifty-four imprinting control region mice were divided into three groups: untreated controls, treatment with IPL, and treatment with MTS. A single pass of IPL 10.5 J/cm(2) and five passes (total 15 strokes) of MTS were performed three times every 2 weeks. Four weeks after the last treatment, skin thickness measurements using a caliper, microscopic examination, Western blot analysis for type I collagen, and enzyme-linked immunosorbent assay for total collagen content were performed.
Measured using calipers, MTS, resulted in greater skin thickness than IPL that paralleled the dermal thickness of the biopsied specimens. MTS also increased expression levels of type I collagen and total collagen content more than IPL. IPL effects were superior to control.
MTS increased collagen deposition more than IPL, and MTS might be more effective than IPL for scar treatment. The authors have indicated no significant interest with commercial supporters.
强脉冲光（IPL）和微针治疗系统（MTS）目前可用于治疗疤痕。人们提出增加胶原蛋白沉积是治疗疤痕的一种机制。
比较 IPL 和 MTS 对胶原蛋白沉积的影响。
将 54 只印迹控制区小鼠分为三组：未处理对照组、IPL 治疗组和 MTS 治疗组。对 IPL 进行单次 10.5 J/cm² 和 MTS 进行 5 次（共 15 次），每 2 周治疗一次，共治疗 3 次。最后一次治疗后 4 周，使用卡尺测量皮肤厚度、显微镜检查、I 型胶原蛋白的 Western blot 分析和总胶原蛋白含量的酶联免疫吸附试验。
卡尺测量结果显示，MTS 导致的皮肤厚度大于 IPL，与活检标本的真皮厚度相平行。MTS 还增加了 I 型胶原蛋白和总胶原蛋白含量的表达水平，高于 IPL。IPL 的效果优于对照组。
MTS 增加胶原蛋白沉积的效果优于 IPL，MTS 治疗疤痕可能比 IPL 更有效。作者表示与商业支持者没有重大利益关系。
