Jeon Ga Won, Jung Yu Jin, Koh Sun Young, Lee Yeon Kyung, Kim Kyung Ah, Shin Son Moon, Kim Sung Shin, Shim Jae Won, Chang Yun Sil, Park Won Soon
Department of Pediatrics, Busan Paik Hospital, Inje University College of Medicine, BusanDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Pediatrics, Cheil General Hospital, Kwandong University College of MedicineDepartment of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, SeoulDepartment of Pediatrics, Bucheon Hospital, Soonchunhyang University, College of Medicine, Bucheon, Korea.
Pediatr Int. 2011 Oct;53(5):683-688. doi: 10.1111/j.1442-200X.2011.03332.x.
The purpose of the present study was to determine the effect of feeding nutrient-enriched preterm formula to preterm infants until 6 months' corrected age (CA) on growth and development in the first 18 months of life.
Very low-birthweight preterm infants were fed preterm formula until term (40 weeks CA). Infants were then assigned to one of three groups and were fed term formula until 6 months' CA (group 1, n= 29); preterm formula to 3 months' CA and then term formula to 6 months' CA (group 2, n= 30); or preterm formula until 6 months' CA (group 3, n= 31). Anthropometry was performed at term, 3, 6, 9, 12, 15, and at s18 months' CA. Mental and psychomotor development were assessed using the Bayley Scales of Infant Development II at 18 months' CA.
Although body weight, length, head circumference and z score for CA at term in group 3 were significantly lower than those of groups 1 and 2, growth rates of these parameters were significantly higher in group 3 up to 18 months CA', as compared to groups 1 and 2. The mental developmental index and psychomotor developmental index of the Bayley test were not significantly different between the three groups.
Very low-birthweight preterm infants fed nutrient-enriched preterm formula until 6 months' CA demonstrated significantly improved growth rates for bodyweight, length and head circumference, and comparable mental and psychomotor development throughout the first 18 months of life.
本研究的目的是确定给早产婴儿喂食营养强化早产配方奶粉至矫正年龄6个月，对其出生后18个月内生长发育的影响。
极低出生体重的早产婴儿在足月（矫正年龄40周）前喂食早产配方奶粉。之后婴儿被分为三组，分别在矫正年龄6个月前喂食足月配方奶粉（第1组，n = 29）；在矫正年龄3个月前喂食早产配方奶粉，之后至矫正年龄6个月喂食足月配方奶粉（第2组，n = 30）；或在矫正年龄6个月前一直喂食早产配方奶粉（第3组，n = 31）。在足月、矫正年龄3个月、6个月、9个月、12个月、15个月和18个月时进行人体测量。在矫正年龄18个月时使用贝利婴儿发展量表第二版评估智力和心理运动发育情况。
虽然第3组婴儿在足月时的体重、身长、头围和矫正年龄的z评分显著低于第1组和第2组，但与第1组和第2组相比，第3组这些参数在矫正年龄18个月前的生长速率显著更高。贝利测试的智力发育指数和心理运动发育指数在三组之间没有显著差异。
极低出生体重的早产婴儿喂食营养强化早产配方奶粉至矫正年龄6个月，在出生后的前18个月内，体重、身长和头围的生长速率显著提高，且智力和心理运动发育相当。
