Department of Radiology, Yamaguchi University Graduate School of Medicine, Minamikogushi, Ube, Japan.
AJR Am J Roentgenol. 2011 Mar;196(3):W298-304. doi: 10.2214/AJR.09.3556.
The purpose of our study was to evaluate the correlation between the Kellgren-Lawrence (KL) radiographic score and the femoral and tibial cartilage volumes determined by MRI in patients with knee osteoarthritis. The effect of meniscal tears and extrusion on the cartilage volume was also examined.
Knee cartilage was evaluated by MRI in 74 patients (20 men and 54 women) who were categorized according to the KL score. Sagittal fat-suppressed 3D spoiled gradient-echo images were obtained to calculate the cartilage volume. The cartilage volume was determined for the lateral femoral cartilage, medial femoral cartilage, lateral tibial cartilage, and medial tibial cartilage. The femoral condylar bone volume was measured to adjust for bone size in each cartilage volume measurement.
After adjusting for age, sex, and femoral condylar bone volume, the cartilage volumes were significantly different between the grades in all compartments. Additionally, significant correlations were observed between the KL score and the adjusted cartilage volumes of lateral femoral cartilage and lateral tibial cartilage without a meniscal tear and between the KL score and the adjusted cartilage volume of medial femoral cartilage with and without a meniscal tear.
These findings showed a significant negative association between cartilage volume and the KL score. The cartilage volume of medial femoral cartilage may be more affected by the severity of osteoarthritis grade than the presence of a meniscal tear. In contrast, the cartilage volume in the lateral tibiofemoral compartment may be easily affected by the presence of a meniscal tear.
本研究旨在评估膝关节骨关节炎患者的 Kellgren-Lawrence（KL）放射评分与 MRI 测定的股骨和胫骨软骨体积之间的相关性。还检查了半月板撕裂和外突对软骨体积的影响。
对 74 名患者（20 名男性和 54 名女性）的膝关节软骨进行 MRI 评估，这些患者根据 KL 评分进行分类。获得矢状位脂肪抑制 3D 扰相梯度回波图像以计算软骨体积。确定外侧股骨软骨、内侧股骨软骨、外侧胫骨软骨和内侧胫骨软骨的软骨体积。测量股骨髁骨体积以调整每个软骨体积测量中的骨大小。
在调整年龄、性别和股骨髁骨体积后，所有节段的等级之间的软骨体积均存在显著差异。此外，在没有半月板撕裂的情况下，KL 评分与外侧股骨软骨和外侧胫骨软骨的调整后软骨体积之间以及有和没有半月板撕裂的情况下 KL 评分与内侧股骨软骨的调整后软骨体积之间存在显著相关性。
这些发现表明软骨体积与 KL 评分之间存在显著的负相关。内侧股骨软骨的软骨体积可能比半月板撕裂的存在更受骨关节炎严重程度的影响。相比之下，外侧胫股关节间室的软骨体积可能容易受到半月板撕裂的影响。
