UMR 144, Centre National de la Recherche Scientifique/Morphogenèse et Signalisation Cellulaires, Institut Curie, Paris, France.
Cell Adh Migr. 2011 Mar-Apr;5(2):199-206. doi: 10.4161/cam.5.2.15081. Epub 2011 Mar 1.
The highly related ERM (Ezrin, Radixin, Moesin) proteins provide a regulated linkage between the membrane and the underlying actin cytoskeleton. They also provide a platform for the transmission of signals in responses to extracellular cues. Studies in different model organisms and in cultured cells have highlighted the importance of ERM proteins in the generation and maintenance of specific domains of the plasma membrane. A central question is how do ERM proteins coordinate actin filament organization and membrane protein transport/stability with signal transduction pathways to build up complex structures? Through their interaction with numerous partners including membrane proteins, actin cytoskeleton and signaling molecules, ERM proteins have the ability to organize multiprotein complexes in specific cellular compartments. Likewise, ERM proteins participate in diverse functions including cell morphogenesis, endocytosis/exocytosis, adhesion and migration. This review focuses on aspects still poorly understood related to the function of ERM proteins in epithelial cell adhesion and migration.
高度相关的 ERM（Ezrin、Radixin、Moesin）蛋白在膜和下面的肌动蛋白细胞骨架之间提供了一种受调控的连接。它们还为响应细胞外线索的信号传递提供了一个平台。在不同的模式生物和培养细胞中的研究强调了 ERM 蛋白在形成和维持质膜特定区域方面的重要性。一个核心问题是 ERM 蛋白如何协调肌动蛋白丝组织和膜蛋白运输/稳定性与信号转导途径，以构建复杂结构？通过与包括膜蛋白、肌动蛋白细胞骨架和信号分子在内的众多伙伴相互作用，ERM 蛋白能够在特定的细胞区室中组织多蛋白复合物。同样，ERM 蛋白参与多种功能，包括细胞形态发生、内吞/外排、黏附和迁移。本综述重点介绍了与 ERM 蛋白在上皮细胞黏附和迁移中的功能相关的仍未被充分了解的方面。
