Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland.
Molecules. 2011 Feb 22;16(2):1854-77. doi: 10.3390/molecules16021854.
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
细胞中的 DNA 损伤会激活核多聚（ADP-核糖）聚合酶（PARPs），并由 PAR 糖基水解酶（PARG）作用将合成的多聚（ADP-核糖）（PAR）迅速切割成 ADP-核糖（ADPR）。天然存在的类单宁分子被认为可以特异性抑制 PARG 酶。本综述讨论了单宁在体外和体内对 PAR 代谢的影响及其在 DNA 损伤信号转导中的下游作用。
