Blanken Carmen P S, Bayer Sandra, Buchner Carro Sophie, Hauner Hans, Holzapfel Christina
Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany.
Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany.
Mol Nutr Food Res. 2025 Feb;69(3):e202400561. doi: 10.1002/mnfr.202400561. Epub 2025 Jan 19.
Insulin responses to standardized meals differ between individuals. This variability may in part be explained by genotype. This systematic review evaluates associations between genotype and insulin response to an oral glucose tolerance test (OGTT) in terms of insulin area under the curve (AUC).
Three electronic databases (Web of Science, Embase, PubMed) were searched for studies investigating associations between insulin AUC after an OGTT and single nucleotide polymorphisms (SNPs) belonging to the transcription factor 7 like 2 (TCF7L2) gene, the peroxisome proliferator-activated receptor gamma (PPARγ) gene, or the potassium inwardly rectifying channel subfamily J member 11 (KCNJ11) gene in persons without diabetes. A total of 5199 articles were identified, of which 38 were included. Among them were family-based studies (9), twin studies (2), and studies with unrelated participants (27). Seventeen articles investigated TCF7L2 (7 SNPs), 14 investigated PPARγ (1 SNP), and 8 investigated KCNJ11 (5 SNPs). For all investigated SNPs, at least half of the reports indicated no statistically significant association with postprandial insulin AUC.
No evidence was found for associations between TCF7L2, PPARγ, and KCNJ11 genotypes and insulin AUC after an OGTT. Future studies should investigate the effect of genetic risk scores on postprandial insulin.
个体对标准化餐食的胰岛素反应存在差异。这种变异性部分可能由基因型解释。本系统评价根据胰岛素曲线下面积（AUC）评估基因型与口服葡萄糖耐量试验（OGTT）胰岛素反应之间的关联。
检索了三个电子数据库（科学网、Embase、PubMed），以查找研究无糖尿病个体OGTT后胰岛素AUC与属于转录因子7样2（TCF7L2）基因、过氧化物酶体增殖物激活受体γ（PPARγ）基因或内向整流钾通道亚家族J成员11（KCNJ11）基因的单核苷酸多态性（SNP）之间关联的研究。共识别出5199篇文章，其中38篇被纳入。其中包括基于家系的研究（9项）、双胞胎研究（2项）以及无关参与者的研究（27项）。17篇文章研究了TCF7L2（7个SNP），14篇研究了PPARγ（1个SNP），8篇研究了KCNJ11（5个SNP）。对于所有研究的SNP，至少一半的报告表明与餐后胰岛素AUC无统计学显著关联。
未发现TCF7L2、PPARγ和KCNJ11基因型与OGTT后胰岛素AUC之间存在关联。未来研究应调查遗传风险评分对餐后胰岛素的影响。
