Markova Roumiana, Drenska Rumiana, Minchev Petko, Todorova Yana, Ciccozzi Massimo, Amicosante Massimo
Laboratory of Mediators of Inflammation and Immunity, Department of Immunology and Allergology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria.
New Microbiol. 2011 Jan;34(1):81-5. Epub 2011 Jan 15.
QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-? responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. QFT-IT responses to TB-specific antigens are not compromised with young age.
对50名患结核病儿童的全血γ干扰素释放试验（QuantiFERON-TB）数据进行分析，以评估年龄相关效应。对结核特异性抗原的γ干扰素（IFN-γ）反应显著较高与年龄较小有关，但丝裂原反应未发现差异。将γ干扰素释放试验（IGRA）反应外推至丝裂原并不能反映抗原特异性刺激所诱导的反应。全血γ干扰素释放试验（QFT-IT）对结核特异性抗原的反应不会因年龄小而受损。
