Neurology II, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126 Turin, Italy.
J Headache Pain. 2011 Apr;12(2):193-9. doi: 10.1007/s10194-011-0314-8. Epub 2011 Feb 23.
The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case-control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ(2)=9.872, p=0.007; χ(2)=8.108, p=0.004) between migraineurs and controls. The carriage of the A allele was associated with an increased migraine risk (OR 1.42, 95% CI 1.11-1.81). When we divided the migraine patients into different subgroups, the difference reached the level of statistical significance only in migraine without aura. The different genotypes had no significant effect on the examined clinical characteristics of the disease. In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.
我们的研究目的是调查下丘脑分泌素受体 1（HCRTR1）基因中的遗传变异是否可以改变偏头痛的发生和临床特征。我们采用病例对照策略，对 384 名偏头痛患者和 259 名对照者进行了 HCRTR1 基因三个 SNP 的基因分型。rs2271933 非同义多态性的基因型和等位基因频率在偏头痛患者和对照组之间存在差异（χ(2)=9.872，p=0.007；χ(2)=8.108，p=0.004）。携带 A 等位基因与偏头痛风险增加相关（OR 1.42，95%CI 1.11-1.81）。当我们将偏头痛患者分为不同亚组时，这种差异仅在无先兆偏头痛中达到统计学意义。不同的基因型对所检查的疾病临床特征没有显著影响。总之，我们的数据支持下丘脑分泌素受体 1 基因可能是无先兆偏头痛的遗传易感因素的假设，并表明下丘脑分泌素系统可能在偏头痛的病理生理学中发挥作用。
