HCRTR2基因的1246G→A多态性与偏头痛无关。

The 1246G-->A polymorphism of the HCRTR2 gene is not associated with migraine.

作者信息

Pinessi L, Binello E, De Martino P, Gallone S, Gentile S, Rainero I, Rivoiro C, Rubino E, Savi L, Valfrè W, Vaula G

机构信息

Neurology II, Headache Centre, Department of Neuroscience, University of Torino, Torino, Italy.

出版信息

Cephalalgia. 2007 Aug;27(8):945-9. doi: 10.1111/j.1468-2982.2007.01347.x. Epub 2007 Jul 23.

DOI:10.1111/j.1468-2982.2007.01347.x

PMID:17645762

Abstract

Studies in experimental animals have suggested that the hypocretin/orexin system may be involved in migraine pathophysiology. Using a case-control design study, we genotyped 246 migraine patients and 239 healthy controls for the 1246G-->A polymorphism of the hypocretin receptor 2 (HCRTR2) gene. Genotypic and allelic frequencies of the examined polymorphism were similarly distributed between cases and controls (chi2 = 2.22, P = 0.14 and chi2 = 2.45, P = 0.29, respectively). When different migraine subgroups were compared (migraine with aura vs. migraine without aura and episodic vs. chronic migraine) no significant difference was found. Comparison of the clinical features of the disease with the 1246G-->A genotypes showed no significant difference. Our data suggest that the HCRTR2 gene is not a genetic risk factor in migraine.

摘要

对实验动物的研究表明，下丘脑分泌素/食欲素系统可能参与偏头痛的病理生理过程。我们采用病例对照设计研究，对246例偏头痛患者和239名健康对照者的下丘脑分泌素受体2（HCRTR2）基因的1246G→A多态性进行基因分型。所检测多态性的基因型和等位基因频率在病例组和对照组之间分布相似（分别为χ2 = 2.22，P = 0.14和χ2 = 2.45，P = 0.29）。当比较不同的偏头痛亚组时（有先兆偏头痛与无先兆偏头痛以及发作性偏头痛与慢性偏头痛），未发现显著差异。将疾病的临床特征与1246G→A基因型进行比较，未发现显著差异。我们的数据表明，HCRTR2基因不是偏头痛的遗传危险因素。