Roccella Michele, Marotta Rosa, Operto Francesca Felicia, Smirni Daniela, Precenzano Francesco, Bitetti Ilaria, Messina Giovanni, Sessa Francesco, Di Mizio Giulio, Loreto Carla, Salerno Monica, Russo Vincenzo, Murabito Paolo, Gallai Beatrice, Esposito Maria, Iacono Diego, Carotenuto Marco
Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.
Department of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Italy.
Front Neurol. 2019 Aug 27;10:932. doi: 10.3389/fneur.2019.00932. eCollection 2019.
Children with migraine headaches appear to have a range of sleep disturbances. The aim of the present study was to assess the NREM sleep instability in a population of school-aged individuals affected by migraine without aura (MoA). Thirty-three children with MoA (20 males, 13 females, mean age 10.45 ± 2.06 years) underwent to overnight Polysomnographic (PSG) recordings and Cyclic Alternating Pattern (CAP) analyses accordingly with international criteria. MoA group showed a reduction in sleep duration parameters (TIB, SPT, TST; ≤ 0.001 for all) and in arousal index during REM sleep and an increase in awakenings per hour (AWK/h) vs. Controls (C) ( = 0.008). In particular, MoA children showed a reduced CAP rate% ( ≤ 0.001), CAP rate% in S1 ( ≤ 0.001) and CAP rate% in SWS ( = 0.004) vs. C. Moreover, A phases distribution were characterized by a reduction in slow wave components (total number CAP A1%, CAP A1 index) ( ≤ 0.001) and an increase of fast components representation (total number of CAP A2% and CAP A3%) ( < 0.001) in MoA vs. C. Moreover, MoA children showed an increased A1 and A2 mean duration ( ≤ 0.001). Our findings show a reduction of arousability in MoA group and lower NREM lower sleep instability associated with MoA in children.
患有偏头痛的儿童似乎存在一系列睡眠障碍。本研究的目的是评估一群无先兆偏头痛（MoA）的学龄个体的非快速眼动睡眠不稳定性。33名患有MoA的儿童（20名男性，13名女性，平均年龄10.45±2.06岁）按照国际标准进行了夜间多导睡眠图（PSG）记录和周期性交替模式（CAP）分析。与对照组（C）相比，MoA组的睡眠时间参数（总睡眠时间、睡眠潜伏期、总睡眠时间；所有参数均≤0.001）以及快速眼动睡眠期间的觉醒指数降低，每小时觉醒次数（AWK/h）增加（=0.008）。特别是，与C组相比，MoA儿童的CAP发生率%（≤0.001）、S1期的CAP发生率%（≤0.001）和慢波睡眠期的CAP发生率%（=0.004）降低。此外，与C组相比，MoA组的A期分布特征为慢波成分减少（CAP A1%总数、CAP A1指数）（≤0.001），快速成分比例增加（CAP A2%和CAP A3%总数）（<0.001）。此外，MoA儿童的A1和A2平均持续时间增加（≤0.001）。我们的研究结果表明，MoA组的唤醒能力降低，儿童中与MoA相关的非快速眼动睡眠不稳定性较低。
