Hitchon P W, Dyste G N, Osenbach R K, Todd M M, Yamada T, Jensen A E
Department of Surgery, University of Iowa Hospitals, Iowa City 52242.
J Spinal Disord. 1990 Sep;3(3):210-9.
Anesthetized sheep were subjected to spinal cord compression to 200 mm Hg at T13 by means of a distensible epidural balloon. Eight animals were subjected to compression for 20 min, 10 animals for 40 min, and 12 animals for 80 min. Spinal cord blood flow (SCBF) and spinal evoked potentials (SEPs) from L7 to C7 and vice versa were measured prior to, during, and 1/2, 1 1/2, 2 1/2, and 3 1/2 h following compression. The traumatized zone manifested a hyperemic response subsequent to balloon withdrawal in the 20-min and 40-min groups. In the 80-min group, SCBF returned to baseline. With compression, SEPs were obliterated in all animals and failed to recover after 3 1/2 h following injury, irrespective of the duration of compression. These results show that reperfusion of the cord following a compressive insult is not accompanied with recovery of SEPs.
通过可扩张的硬膜外球囊在T13水平将麻醉的绵羊脊髓压迫至200毫米汞柱。8只动物压迫20分钟，10只动物压迫40分钟，12只动物压迫80分钟。在压迫前、压迫期间以及压迫后1/2、1 1/2、2 1/2和3 1/2小时测量从L7到C7以及反之的脊髓血流（SCBF）和脊髓诱发电位（SEPs）。在20分钟和40分钟组中，球囊撤出后创伤区域出现充血反应。在80分钟组中，SCBF恢复到基线水平。压迫时，所有动物的SEP均消失，且损伤后3 1/2小时未能恢复，与压迫持续时间无关。这些结果表明，压迫性损伤后脊髓再灌注并未伴随SEP的恢复。
