Hitchon P W, McKay T C, Wilkinson T T, Girton R A, Hansen T, Dyste G N
Department of Surgery, University of Iowa, Iowa City.
Spine (Phila Pa 1976). 1989 Jan;14(1):16-22. doi: 10.1097/00007632-198901000-00004.
In acute nonsurvival studies, eight anesthetized lambs were subjected to cord compression at T13 by means of an epidural balloon distended to a pressure of 200 mm Hg for 40 minutes. Subsequent to withdrawal of the balloon, each animal received 30 mg/kg of methylprednisolone succinate in an intravenous bolus followed by a continuous infusion of 10 mg/kg/hr for the duration of the experiment. Spinal cord blood flow (SCBF) and spinal evoked potential (SEP) determinations were obtained sequentially prior to, during, and at 1/2, 1 1/2, and 2 1/2 hours following compression. In spite of the absence of ischemia following compression, SEPs failed to recover. Methylprednisolone had no apparent effect on blood flow or on the recovery of SEPs when compared with results in ten control animals that received saline alone.
在急性非存活研究中，八只麻醉的羔羊通过硬膜外球囊在T13水平进行脊髓压迫，球囊扩张至200毫米汞柱的压力并维持40分钟。在撤出球囊后，每只动物静脉推注30毫克/千克的琥珀酸甲泼尼龙，随后在实验期间以10毫克/千克/小时的速度持续输注。在压迫前、压迫期间以及压迫后1/2小时、1 1/2小时和2 1/2小时依次测定脊髓血流量（SCBF）和脊髓诱发电位（SEP）。尽管压迫后不存在缺血情况，但SEP未能恢复。与十只仅接受生理盐水的对照动物的结果相比，甲泼尼龙对血流量或SEP的恢复没有明显影响。
