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Amides as excellent mimics of phosphate linkages in RNA.

作者信息

Selvam Chelliah, Thomas Siji, Abbott Jason, Kennedy Scott D, Rozners Eriks

机构信息

Department of Chemistry, Binghamton University, The State University of New York, Binghamton, NY 13902, USA.

出版信息

Angew Chem Int Ed Engl. 2011 Feb 25;50(9):2068-70. doi: 10.1002/anie.201007012. Epub 2011 Jan 21.

DOI:10.1002/anie.201007012
PMID:21344553
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3516995/
Abstract
摘要

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Curr Protoc Nucleic Acid Chem. 2010 Dec;Chapter 7:Unit 7.14. doi: 10.1002/0471142700.nc0714s43.
2
RNA internal loops with tandem AG pairs: the structure of the 5'GAGU/3'UGAG loop can be dramatically different from others, including 5'AAGU/3'UGAA.具有串联 AG 对的 RNA 内部环：5'GAGU/3'UGAG 环的结构可能与其他环（包括 5'AAGU/3'UGAA）有很大的不同。
Biochemistry. 2010 Jul 13;49(27):5817-27. doi: 10.1021/bi100332r.
3
Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
引导链种子区的酰胺修饰可提高短干扰 RNA 的靶标特异性。
ACS Chem Biol. 2023 Jan 20;18(1):7-11. doi: 10.1021/acschembio.2c00769. Epub 2022 Dec 29.
4
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.一种增强硫代磷酸酯外显子跳跃寡核苷酸细胞摄取和活性的 LNA-酰胺修饰。
Nat Commun. 2022 Jul 12;13(1):4036. doi: 10.1038/s41467-022-31636-2.
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Chemical Modifications of CRISPR RNAs to Improve Gene-Editing Activity and Specificity.化学修饰 CRISPR RNA 以提高基因编辑活性和特异性。
J Am Chem Soc. 2022 Jul 20;144(28):12584-12594. doi: 10.1021/jacs.2c02633. Epub 2022 Jul 7.
6
Optimization of Automated Synthesis of Amide-Linked RNA.酰胺连接的RNA自动合成的优化
ACS Omega. 2022 May 31;7(23):20420-20427. doi: 10.1021/acsomega.2c02742. eCollection 2022 Jun 14.
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Chemical strategies for strand selection in short-interfering RNAs.短干扰RNA中链选择的化学策略。
RSC Adv. 2021 Jan 11;11(4):2415-2426. doi: 10.1039/d0ra07747j. eCollection 2021 Jan 6.
8
Beyond ribose and phosphate: Selected nucleic acid modifications for structure-function investigations and therapeutic applications.超越核糖与磷酸：用于结构功能研究及治疗应用的特定核酸修饰
Beilstein J Org Chem. 2021 Apr 28;17:908-931. doi: 10.3762/bjoc.17.76. eCollection 2021.
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Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA-Gapmer Approach.朝着具有改善性能的两性离子寡核苷酸迈进：NAA/LNA-Gapmer 方法。
Chembiochem. 2020 Nov 16;21(22):3234-3243. doi: 10.1002/cbic.202000450. Epub 2020 Aug 28.
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Amide-Modified RNA: Using Protein Backbone to Modulate Function of Short Interfering RNAs.酰胺修饰 RNA：利用蛋白质骨架调节短干扰 RNA 的功能。
Acc Chem Res. 2020 Sep 15;53(9):1782-1790. doi: 10.1021/acs.accounts.0c00249. Epub 2020 Jul 13.
在甲缩醛修饰的寡核苷酸中结构、水合作用和热稳定性的相互作用：RNA 可能比 DNA 更能耐受非离子修饰。
J Am Chem Soc. 2009 Oct 21;131(41):14932-7. doi: 10.1021/ja904926e.
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Solid-phase synthesis of modified RNAs containing amide-linked oligoribonucleosides at their 3'-end and their application to siRNA.3'-末端含有酰胺连接的寡核糖核苷的修饰RNA的固相合成及其在小干扰RNA中的应用。
Nucleosides Nucleotides Nucleic Acids. 2007;26(10-12):1451-4. doi: 10.1080/15257770701542389.
6
Chemical modification: the key to clinical application of RNA interference?化学修饰：RNA干扰临床应用的关键？
J Clin Invest. 2007 Dec;117(12):3615-22. doi: 10.1172/JCI33483.
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9
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10
Synthesis and properties of RNA analogues having amides as interuridine linkages at selected positions.在选定位置具有酰胺作为尿苷间连接键的RNA类似物的合成与性质
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