通过还原膦化过程将酰胺直接转化为α-氨基膦酸酯。
Direct transformation of amides into α-amino phosphonates via a reductive phosphination process.
机构信息
Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
出版信息
Org Lett. 2013 Aug 16;15(16):4214-7. doi: 10.1021/ol4019419. Epub 2013 Aug 2.
PMID:23909613
Abstract
The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to α-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.
摘要
一种用于酰胺一锅还原膦化的通用方法已被开发。所描述的反应为合成α-氨基膦酸酯提供了一种新颖的方法，具有良好到优秀的收率，涵盖了广泛的底物范围，如仲胺和叔胺，并且不需要低温条件。
Zotero 插件