Department of Chemistry, College of Chemistry and Chemical Engineering, and the Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China.
Org Lett. 2013 Aug 16;15(16):4214-7. doi: 10.1021/ol4019419. Epub 2013 Aug 2.
The first general method for the reductive phosphination of amides in one pot has been developed. The reactions described provide a novel access to α-amino phosphonates in good to excellent yields, cover a broad scope of substrates such as secondary and tertiary amides, and do not require a low temperature.
一种用于酰胺一锅还原膦化的通用方法已被开发。所描述的反应为合成α-氨基膦酸酯提供了一种新颖的方法，具有良好到优秀的收率，涵盖了广泛的底物范围，如仲胺和叔胺，并且不需要低温条件。
