Public Health Institute of Navarre, Pamplona, Spain.
Euro Surveill. 2011 Feb 17;16(7):19799.
We defined a cohort of people with major chronic conditions (152,585 subjects) in Navarre, Spain, using electronic records from physicians, to obtain 2010/11 mid-season estimates of influenza vaccine effectiveness. The adjusted estimates of the effectiveness of the 2010/11 trivalent influenza vaccine were 31% (95% confidence interval (CI): 20–40%) in preventing medically attended influenza-like illness, and 58% (95% CI: 11–80%) in preventing laboratory-confirmed influenza. Having received the monovalent influenza A(H1N1)2009 vaccine in the 2009/10 season had an independent preventive effect against medically attended influenza-like illness (17%, 95% CI: 1–30%), and having received both vaccines had 68% (95% CI: 23–87%) effectiveness in preventing laboratory-confirmed influenza.
我们在西班牙纳瓦拉地区利用医生的电子病历定义了一组患有主要慢性疾病的人群（152585 例），以获得 2010/11 年流感疫苗效力的 2010/11 年中期估计值。2010/11 年三价流感疫苗预防有医疗记录的流感样疾病的调整后估计效力为 31%（95%置信区间（CI）：20-40%），预防实验室确诊流感的效力为 58%（95%CI：11-80%）。在 2009/10 年季节接种单价流感 A(H1N1)2009 疫苗对有医疗记录的流感样疾病具有独立的预防作用（17%，95%CI：1-30%），而接种两种疫苗对实验室确诊流感的预防效果为 68%（95%CI：23-87%）。
