Instituto de Salud Pública de Navarra, Pamplona, Spain.
Vaccine. 2011 Aug 11;29(35):5919-24. doi: 10.1016/j.vaccine.2011.06.063. Epub 2011 Jun 30.
We defined a population-based cohort (596,755 subjects) in Navarre, Spain, using electronic records from physicians, to evaluate the effectiveness of the monovalent A(H1N1)2009 vaccine in preventing influenza in the 2009-2010 pandemic season. During the 9-week period of vaccine availability and circulation of the A(H1N1)2009 virus, 4608 cases of medically attended influenza-like illness (MA-ILI) were registered (46 per 1000 person-years). After adjustment for sociodemographic covariables, outpatient visits and major chronic conditions, vaccination was associated with a 32% (95% CI: 8-50%) reduction in the overall incidence of MA-ILI. In a test negative case-control analysis nested in the cohort, swabs from 633 patients were included, and 123 were confirmed for A(H1N1)2009 influenza. No confirmed case had received A(H1N1)2009 vaccine versus 9.6% of controls (p<0.001). The vaccine effectiveness in preventing laboratory-confirmed influenza was 89% (95% CI: 36-100%) after adjusting for age, health care setting, major chronic conditions and period. Pandemic vaccine was effective in preventing MA-ILI and confirmed cases of influenza A(H1N1)2009 in the 2009-2010 season.
我们在西班牙纳瓦拉地区利用医生的电子记录定义了一个基于人群的队列（596755 人），以评估单价 A（H1N1）2009 疫苗在 2009-2010 大流行季节预防流感的效果。在疫苗供应和 A（H1N1）2009 病毒传播的 9 周期间，登记了 4608 例经医学证实的流感样疾病（MA-ILI）病例（每 1000 人年 46 例）。在调整了社会人口统计学协变量、门诊就诊和主要慢性疾病后，接种疫苗与 MA-ILI 总发病率降低 32%（95%CI：8-50%）相关。在该队列中嵌套的阴性病例对照测试分析中，纳入了 633 名患者的拭子，其中 123 例被确认为 A（H1N1）2009 流感。没有确诊病例接种过 A（H1N1）2009 疫苗，而对照组有 9.6%的人接种过（p<0.001）。在调整年龄、医疗保健环境、主要慢性疾病和时期后，预防实验室确诊流感的疫苗有效性为 89%（95%CI：36-100%）。大流行疫苗在 2009-2010 年季节有效预防了 MA-ILI 和确诊的 A（H1N1）2009 流感病例。
