UPRES EA, Univ. Paris-Sud, Faculté de Pharmacie, Châtenay-Malabry, France.
Arch Biochem Biophys. 2011 Jun 15;510(2):83-92. doi: 10.1016/j.abb.2011.02.012. Epub 2011 Feb 21.
Microtubule dynamics is controlled and amplified in vivo by complex sets of regulators. Among these regulatory proteins, molecular motors from the kinesin superfamily are taking an increasing importance. Here we review how microtubule disassembly or assembly into interphase microtubules, mitotic spindle or cilia may involve kinesins and how protein kinases may participate in these kinesin-dependent regulations.
微管动力学在体内受到复杂的调控因子的控制和放大。在这些调节蛋白中，驱动蛋白超家族的分子马达越来越受到重视。在这里，我们回顾了微管的解聚或组装成间期中微管、有丝分裂纺锤体或纤毛可能涉及的驱动蛋白，以及蛋白激酶如何参与这些依赖于驱动蛋白的调节。
