Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
Trends Cell Biol. 2012 Nov;22(11):567-75. doi: 10.1016/j.tcb.2012.08.003. Epub 2012 Sep 6.
The stereotypical function of kinesin superfamily motors is to transport cargo along microtubules. However, some kinesins also shape the microtubule track by regulating microtubule assembly and disassembly. Recent work has shown that the kinesin-8 family of motors emerge as key regulators of cellular microtubule length. The studied kinesin-8s are highly processive motors that walk towards the microtubule plus-end. Once at plus-ends, they have complex effects on polymer dynamics; kinesin-8s either destabilize or stabilize microtubules, depending on the context. This review focuses on the mechanisms underlying kinesin-8-microtubule interactions and microtubule length control. We compare and contrast kinesin-8s with the other major microtubule-regulating kinesins (kinesin-4 and kinesin-13), to survey the current understanding of the diverse ways that kinesins control microtubule dynamics.
驱动蛋白超家族马达的典型功能是沿微管运输货物。然而，一些驱动蛋白也通过调节微管的组装和拆卸来塑造微管轨道。最近的工作表明，驱动蛋白-8 家族的马达成为细胞微管长度的关键调节因子。研究过的驱动蛋白-8 是高度连续的马达，它们朝着微管的正极方向行走。一旦到达正极，它们对聚合物动力学有复杂的影响；驱动蛋白-8 要么使微管不稳定，要么稳定微管，这取决于具体情况。这篇综述重点介绍了驱动蛋白-8 与微管相互作用和微管长度控制的机制。我们比较和对比了驱动蛋白-8 与其他主要的微管调节驱动蛋白（驱动蛋白-4 和驱动蛋白-13），以了解驱动蛋白控制微管动力学的不同方式的现有认识。
